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The role of inflammation in the pathophysiology of DMO
1 February 2016
| Fiona Harris, Spyridon Chalkiadakis, Simon Taylor (Prof)
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EYE - Vitreo-Retinal
Diabetic macular oedema (DMO) is a major cause of visual loss in diabetes, with a complex multifactorial pathogenesis. In the UK alone it is estimated that there are nearly 2.5 million diabetic patients aged over 12 years. Approximately 65,000 of...
An anterior segment lump: a diagnostic and treatment challenge
Case presentation A 50-year-old female presented to eye casualty with a lump on the left medial lower eyelid with associated redness and occasional bleeding. The lump was present for a few months with recent enlargement (Figure 1). Her past medical...Brain tumours in adults: the essentials for an ophthalmologist
The author provides a review of the common intracranial tumours in adults (other than pituitaries) which may present to an ophthalmologist. Primary malignant brain tumours comprise 3% of adult cancers but with an ageing population such tumours are becoming more...The eye without tears
1 June 2016
| Hector Bryson Chawla
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EYE - General
The Art is long and Life is short. So goes the dispiriting tag in Latin and flung from day one and at regular intervals thereafter at idle medical students who, inevitably brainwashed, come by graduation to believe that the only...
Accuracy of clinician vs. radiologic interpretation of the imaging of orbital lesions
This is a retrospective study of 242 patients who underwent surgical orbitomy at University of California Davis Health between 1 January 2000 and 20 May 2019. The preoperative imaging with radiologist’s interpretation, clinical assessment with clinician’s interpretation of imaging, and...
Distribution, progression, and outcomes of inflammatory chorioretinal lesions
1 December 2022
| Kelvin Cheng
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EYE - Vitreo-Retinal
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Autofluorescence, inflammatory lesions, multifocal choroiditis, multimodal imaging, optical coherence tomography, punctate inner choroidopathy, uveitis
This study investigated the distribution and progression of multifocal choroiditis (MFC) inflammatory lesions in 25 eyes of 20 patients and their correlations with clinical outcomes at 24 months. The distribution of choroiditis inflammatory lesions were evaluated semi-automatically using a dedicated...
Microbial keratitis in corneal grafts
The authors report a retrospective case series of 59 episodes of microbial keratitis identified in 41 eyes of 41 patients (39 penetrating keratoplasty (PKPs) and two deep anterior lamellar keratoplasty (DALKs)), from a total of 759 consecutive corneal grafts identified...
Visual prognosis in Irish Leber’s hereditary optic neuropathy
1 December 2022
| Claire Howard
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EYE - Neuro-ophthalmology
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Leber’s hereditary optic neuropathy, idebenone, inherited optic neuropathy, mtDNA, ophthalmic genetics, optic atrophy
Leber’s hereditary optic neuropathy (LHON) is an inherited optic neuropathy This paper presents a retrospective review of clinical data from patients with LHON presenting to an Irish tertiary referral ophthalmic hospital. Clinical and genetic characteristics were assessed for useful biomarkers...
Clinical relevance of the anatomic classification of neovascular age-related macular degeneration
The author explains why an OCT-based classification of neovascular AMD is needed and how these neovascular subtypes may help to predict patients’ long-term visual outcome. Age-related macular degeneration (AMD) is a chronic and progressive neurodegenerative process involving the macula in...
Differential diagnosis in cases of suspected neuroretinitis
1 June 2016
| Claire Howard
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EYE - Neuro-ophthalmology
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Cat scratch disease, macular star, neuroretinitis, optic disc oedema, rickettsiosis, systemic hypertension
Neuroretinitis is a form of optic neuropathy typically characterised by acute unilateral visual loss with optic disc oedema and macular exudates arranged in a star figure around the fovea (complete or partial star). The purpose of this study was to...
Retrospective review of visual outcomes in Idiopathic intracranial hypertension (IIH)
1 December 2022
| Claire Howard
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EYE - Neuro-ophthalmology
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Idiopathic intracranial hypertension, Pseudotumor cerebri, visual outcome
Idiopathic intracranial hypertension (IIH) is a clinical syndrome characterised by headache and papilloedema that can lead to significant visual morbidity. IIH is diagnosed by the modified Dandy criteria, which include normal neuroimaging and cerebrospinal fluid (CSF) composition, high CSF opening...
Reflections on a twelve-year partnership: The Makassar-Dundee LINK
3 June 2021
| John Ellis, Habibah Muhiddin, Andi Muhammad Ichsan, Marcia Zondervan
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EYE - Paediatrics, EYE - Strabismus, EYE - General
In the first article of a two-part series (see Part 2 here), the authors provide an overview of this hugely successful partnership and how they overcame the challenges of COVID-19. What began in 2008 as a connection between equals, has...
