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Importing iron to the retina

In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...

Primary intravenous chemotherapy (IVC) for Group D retinoblastoma

A retrospective review is reported of 64 group D retinoblastoma (RB) eyes (52 patients) treated with primary IVC, between 2002 and 2014 from two centres, in the UK and US. The median age at presentation was 11 months, 35 (67%)...

Vitrectomy after ocriplasmin for VVMT adhesion of MH study

This is a multicentre retrospective study of 51 eyes that received intravitreal ocriplasmin between January 2013 to January 2014 for symptomatic vitreomacular (VMT) +/- macular hole (MH), and then went on to PPV for persistent pathology, comparing a control group...

Treat and extend for PCV

This South Korean study investigated the efficacy of a treat and extend regimen (TER) using ranibizumab to treat polypoidal choroidal vasculopathy (PCV). Twenty-nine eyes were included in this retrospective case note review. Of these, five eyes had been treated with...

Review of paediatric infectious endophthalmitis

This paper presents a review on paediatric infectious endophthalmitis and considers aetiology, prognosis and management. Classification included exogenous and endogenous. Diagnosis was based on presenting history, signs and symptoms, cultures and imaging. Exogenous cases included postoperative endophthalmitis (strabismus surgery, glaucoma...

Methotrexate and mycophenolate mofetil for non-infectious uveitis

This is the first reported randomised clinical trial comparing methotrexate versus mycophenolate mofetil (MMF) for the treatment of non-infectious intermediate uveitis, posterior uveitis or panuveitis. To be eligible for recruitment, patients had to be on ≥15mg oral prednisone and demonstrated...

Complications with porous orbital implant after enucleation in retinoblastoma patients

This is a retrospective, case control study aimed to identify risk factors associated with complications in retinoblastoma patients following primary and secondary enucleations with porous implant placements. Patients with retinoblastoma who underwent enucleation with porous orbital implant placement between January...

Vitrectomy in retinal detachment associated with choroidal detachment

Hypotony, posterior retinal breaks, longer axial lengths and total retinal detachments (RD) are risk factors for development of RD associated with choroidal detachment (RRDCD). This study retrospectively analysed the anatomic outcomes and prognostic factors of vitrectomy in 175 patients with...

Control of bleeding with diabetic vitrectomy under air

The authors describe a modified diabetic vitrectomy using continuous air infusion in diabetic eyes with severe fibrovascular proliferation. In their case series of 25 eyes (20 patients), intravitreal bevacizumab (1.25mg) was used one week prior to surgery. Fifteen eyes had...

Prognostic factors for visual acuity in patients with LHON after gene therapy

This retrospective study investigates prognostic factors affecting the visual acuity after a single intravitreal injection of rAAV2-ND4 gene therapy in 53 patients with Leber’s hereditary optic neuropathy (LHON) with mutation at site 11 778. Patients were reviewed one and three...

Ozurdex in epiretinal membrane surgery

This was a prospective multicentre pilot study, looking at the effect of Ozurdex on visual acuity (VA) and central retinal thickness (CRT) in patients undergoing surgery for epiretinal membrane (ERM). Twelve eyes of 12 patients were included in the study....

Effect of blue-light filtering intraocular lenses on age-related macular degeneration

This is a retrospective cohort study evaluating whether blue-light filtering (BLF) intraocular lenses (IOL) offer prophylaxis for neovascular age-related macular degeneration (nAMD). The study included 11,397 eyes of 11,397 patients with a mean age of 75.4 ±8.3 years that underwent...