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Fenofibrate and diabetic retinopathy
Fenofibrate is an agonist of peroxisome proliferator-activated receptor-alpha (PPARα) which is used as a lipid-lowering agent. By reducing blood lipid levels, it can decrease retinal hard exudates which is beneficial in diabetic retinopathy (DR). FIELD and ACCORD studies show that...Ophthalmology assessment using Revised Bloom’s Taxonomy
Bloom’s Taxonomy is a hierarchical list of attributes and skills that facilitates teachers to effectively teach, whilst concurrently enabling learners to effectively learn. It was first developed in 1956 by Benjamin Bloom, an educational psychologist along with a team of...The Global Vision Database
The overall goal of the Global Vision Database (GVD) [1] is to develop and deploy new and improved evidence on the prevalence of blindness and vision impairment (VI) globally. It is a repository which allows us to assess the causes...Diary from my elective: a Parisian experience
The author explains how a research institute’s dedication to multidisciplinary collaboration helped him to discover a passion for academic ophthalmology. The elective aspect to the final year of a medical degree, through its change of scenery and immersion into another...Prevalence of acute anterior uveitis in diabetic patients attending diabetic eye disease clinics
The authors share their investigation at Manchester Royal Eye Hospital into the association between diabetes and AAU. The global prevalence of diabetes mellitus (DM) is rapidly rising from an estimated 9.3% in 2019 to 10.2% by 2030 [1]. The link...
Importing iron to the retina
In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...FMLM Conference 2024
by Somain Verma, Ophthalmology Registrar (ST2), Northampton General Hospital. Clinical leadership is more important than ever. With an ever-increasingly burdened health system, we must assure that appropriate resources and systems are in place to maintain an effective and efficient health...
Fingolimod: ocular adverse effects
In this article the authors review the ocular side-effects of Fingolimod which is an oral immunomodulating drug used in the management of relapsing-remitting multiple sclerosis (RRMS). Fingolimod-associated macular oedema (FAME) is the most common ocular side-effect linked to this drug....
Association of dry eye symptoms in patients with dyslipidaemia and statin use
This retrospective analysis of the Blue Mountains Eye Study III cohort (Caucasian Australians residing west of Sydney n=1680; mean age >74 years, range 60-97) analysed the association between dyslipidaemia, use of oral statins and symptoms of dry disease (DED) among...Exploiting nature’s randomised trials of eye disease
Confounding and reverse causation in observational ophthalmic epidemiology Traditional observational studies are inherently limited in establishing a causal effect of an exposure on an outcome of interest. One fundamental limitation is confounding, whereby causation is incorrectly attributed to a third...
RTP801 as a neuroprotective and axon regenerative treatment
This paper describes the neuroprotective and axon regenerative effects of siRTP801, which is a translatable small-interfering RNA (siRNA) targeting mTOR negative regulator; RTP801, through in-vivo and in-vitro models. In-vivo studies involved an optic nerve crush rat model with intravitreal injections...
