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Intravitreal dexamethasone implant for diabetic macular oedema
The authors report on the three-year outcomes of the Ozurdex Dexamethasone (DEX) intravitreal implant multi-centre trial for the treatment of diabetic macular oedema (DME). Patients with DME (best-corrected vision of 20/50 to 20/200 and central retinal thickness of ≥300µm) were...
Transcriptomic analysis of ocular tissues
Transcriptomics is defined as the analysis of the complete set of RNA transcripts present in a cell under different circumstances, quiescent versus challenge, by microarray analysis. Comparison of transcriptomes identifies genes that are differentially expressed in different cell populations under...
Imaging and histological relationship of orbital Schwannomas
This is a retrospective review of 15 patients with orbital Schwannomas comparing the radiological characteristics, in particular the signal intensity on MRI, with the histological sub-types of the tumours. Five patients had MRI imaging alone, three had CT alone and...
Macular thickness and visual fields
The authors describe a comparison of spectral domain OCT with Humphrey visual fields (HVF) mean deviation (MD) and pattern standard deviation (PSD), examining the retinal thickness of the macula and circumpapillary retinal nerve fibre layer (RNFL) defects. Seventy-three subjects who...
Expert vs. non expert grading of ROP from digital video images
The primary purpose of this study was to determine whether digital video images of the retina obtained using an indirect ophthalmoscope imaging system could be accurately graded for zone and stage of retinopathy of prematurity (ROP) and the presence of...
Mitomycin C versus 5-FU as an adjunctive treatment for trabeculectomy
Antifibrotic agents are used during trabeculectomy (TRAB) to improve long-term surgical success by reducing fibrosis of subconjunctival and episcleral tissue. The purpose of this meta-analysis was to directly compare the efficacy and safety of the two most frequently used antifibrotic...
Moxifloxacin 0.5% for bacterial keratitis
The authors report on the results of a randomised controlled trial comparing commercially available non-preserved moxifloxacin 0.5% vs. a combination of fortified cefazolin 5% and tobramycin 1.3% in the treatment of moderate bacterial keratitis without perforation. Corneal scrapings were collected...
Intracameral mydriasis with Mydrane
The aim of this study is to evaluate the ‘real world’ experience in a UK setting for intracameral Mydrane mydriasis in routine cataract surgery. A prospective consecutive series of 60 patients (group 2) had intraoperative, intracameral Mydrane (tropicamide 0.02%, phenylephrine...
Results of four years of implantation of XEN glaucoma gel stent
This multi-centred prospective, non-randomised study presents the long-term clinical outcomes in patients after implantation of transscleral XEN Glaucoma Gel Microstent, 63μm. (XEN-GGM, Allergan, New Jersey). It was conducted in Austria, Canada and Germany. Sixty-four consecutive eyes of 64 patients with...
Comparison of vertical rectus muscle transpositions
The purpose of this study was to evaluate both the amount of correction obtained and the postoperative drift that occurred with two frequently used vertical rectus muscle transposition (VRT) procedures to determine the ideal immediate postoperative alignment. Twenty-seven patients underwent...
Outcomes of early versus late surgery for infantile esotropia
The authors aimed to provide a better understanding of the clinical spectrum of infantile esotropia by comparing motor and sensory results in the long-term follow-up of patients who underwent surgery. This was a retrospective review over a 17-year period. There...
