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2274 results found

RPTP-σ increases pro-MMP activity in a trabecular meshwork cell line following oxidative stress conditions

This study aims to outline the role of phosphatases in the aqueous drainage system by overexpressing receptor tyrosine phosphatase sigma (RPTP-σ) in a human normal trabecular meshwork cell line and describing its effect on subtypes of matrix metalloproteinases (MMP) and...

Systemic anti-inflammatory versus fluocinolone acetonide intraocular implant

In the Multicenter Uveitis Steroid Treatment (MUST) trial, 255 patients with intermediate uveitis, posterior uveitis or panuveitis were randomised to either fluocinolone acetonide intraocular implant or systemic corticosteroid therapy which was supplemented with immunosuppression if required. Patients were followed up...

Ozurdex wound leakage

This letter to the editor describes two cases of wound leakage after Ozurdex injection. The first case is a man who had four previous injections for an underlying diagnosis of chronic serpiginous choroiditis, who was also on a course of...

PD-1 and retinal ganglion cell death

Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...

Early diagnosis of pituitary apoplexy using combined MRI findings

The author presents a literature review searching the terms ‘pituitary ring sign’ and ‘sphenoid sinus mucosal thickening’ in the context of pituitary apoplexy from 1990 until the present day. These two findings are both magnetic resonance imaging (MRI) signs of...

Effectiveness and Safety of Dexamethasone implants for post surgical macular oedema including Irvine-gass syndrome

This is a retrospective, multicentre, uncontrolled, consecutive case series from Lyon, France between April 20111 to June 2014, with minimum of one year follow-up. The clinical features including the best corrected acuity (BCVA), central subfield macular thickness (CSMT) and intraocular...

Amblyopic choroidal thickness

The authors studied choroidal thickness in 38 paediatric cases (76 eyes) with unilateral amblyopia to evaluate the differences between amblyopic and fellow eyes, and compare them with 19 healthy control subjects (38 eyes). Anisometropic amblyopia was present in 17 cases...

The impact of conjunctivochalasis on dry eye symptoms and signs

The study aimed to draw a relationship between conjunctivochalasis and dry eye symptoms via a dry eye questionnaire (DEQ5), as well as signs such as tear osmolarity, tear break up time, corneal staining, Schirmer score, meibomian gland dropout, eye lid...

Sustained elevation of extracellular ATP in chronic glaucoma

Although adenosine 5′-triphosphate (ATP) release from retinal neurons and astrocytes has been demonstrated in short-term increases in intraocular pressure (IOP); such as in aqueous humor of humans with primary acute angle closure glaucoma, the response in chronic IOP elevation was...

Neuro-ophthalmological symptoms in patients with cerebral venous sinus thrombosis

The authors of this article have evaluated the neuro-ophthalmological symptoms of 49 patients with cerebral venous sinus thrombosis. They have evaluated the onset of the disease as well as the symptoms reported. The authors present extensive clinical information for individual...

Binocular summation with low contrast

The magnitude of binocular summation was investigated in normal control subjects using four different letter charts of varying type with fixed and variable contrast levels and spatial frequency to determine which tests most readily reveal binocular summation in normal subjects....

Atropine penalisation for amblyopia in the UK

The authors aimed to determine the current clinical practice of atropine penalisation (AP) in the UK, to identify perceived barriers limiting use of AP as a first line treatment and ascertain whether any of the barriers could be resolved. An...