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A mouse model for uveal melanoma
Uveal melanoma (UM) is the most common malignant tumour arising within the eye and is a severe threat for both sight and life, due to a high risk of metastasis. There are no animal models of UM, but the Tg(Grm1)...
The presentation of natural killer / T cell lymphoma to the oculoplastic surgeon
The authors present three cases of periorbital extranodal natural killer / T cell lymphoma (ENKL). Ages were 20, 45 and 55. All of these patients presented with painless eyelid swelling and a history of sinus disease. One patient had persistent...
Neurotrophic keratitis
The authors present an overview of the aetiology, diagnosis, current and future management options of neurotrophic keratitis. This is a degenerative corneal disease that occurs following the compromise of trigeminal innervation, leading to hypoesthesia and / or anaesthesia. The aetiology...
Melphalon treatment of retinoblastoma
The purpose of this study was to report the authors’ experience with superselective ophthalmic artery infusion of Melphalon (SOAIM) for the treatment of five cases of unilateral sporadic retinoblastoma involving the macula. Standard therapy included a cycle of three infusions...
Akimba mice, a model of human diabetic retinopathy
Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...
MicroRNA inhibits corneal neovascularisation
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...
Topical doxycycline for corneal neovascularisation
Six eyes with corneal vascularisation were treated with 1% topical doxycycline, four times a day for three weeks. The patients were reviewed at various intervals over a period of one year. The eyes selected had neovascularisation secondary to a variety...
TAC testing in dementia
The aim was to assess the visual acuity measurements performed by the preferential looking method using Teller acuity cards (TAC) in elderly subjects with dementia due to probable Alzheimer’s disease. The mean age was 78.2±9.11 years for patients and 77.2±6.19...
Is laser refractive surgery safe for patients taking isotretinoin?
This multicentre, retrospective, interventional case series assesses the outcomes of laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) in 113 patients taking isotretinoin between January 2003 and September 2017. Isotretinoin is contraindicated for LASIK and PRK and patients are...
Association between neuro-ophthalmology signs and chronic ataxia in children
Neuro-ophthalmological signs (N-OS) occur commonly in children with chronic ataxia. This study describes the N-OS and their frequencies, in general and by specific disease aetiology in paediatric patients with chronic ataxia. In total, 184 patients under the age of 17...
Systemic rituximab immunotherapy in the management of primary ocular adnexal lymphoma single institutional experience
Ocular adnexal lymphomas constitute 2% of all non-Hodgkin’s disease and 5-15% of all extranodal lymphomas and are usually localised, low-grade and of B-cell origin. This opens them up to potential treatment with a systemic monoclonal antibody-based drug (rituximab) directed at...
