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Life in the glaucoma laboratory
When people ask me what life in the laboratory is really like, I often pause. On one hand, it is the romantic notion of pushing back the boundaries of science with the daily rhythm of experiments, data and easily obtained...A Doctors.net.uk app and more security woes
Doctors.net.uk gets a new app The Doctors.net.uk website is well known in the medical community. Its online services started 20 years ago, in 1998! Since then it has retained its core features of providing email accounts and also an online...Embryology in clinical practice
The fascinating world of embryology is both beautiful and practical. It is a home video of our evolutionary history through the ages from the single cell through to the life aquatic, the development of gut, limbs and brain, and most...The ghost of Christmas present
“Ah, youth is wasted on the wrong people.” Some will recognise this as one of the many brilliant quotes from what is considered to be the best Christmas movie ever – Frank Capra’s tear-jerker It’s a Wonderful Life (1946), although...Improved efficacy expected with second-generation microinvasive glaucoma surgery (MIGS) devices
Microinvasive surgical approaches to primary open-angle glaucoma (POAG) offer minimally traumatic options for effective intraocular pressure (IOP) reduction in appropriately selected glaucoma patients. Increases in laser trabeculoplasty rates and wider adoption of glaucoma drainage device filtration procedures, together with the...Collaborative care: The advanced practitioner in paediatric ophthalmology
In response to the increasing paediatric workforce shortage the landscape of paediatric ophthalmology is shifting [1]. As we face a striking surge in demand accompanied by increasingly complex patient profiles, alternative models of care are beginning to evolve. The advanced...Blind Golf Scotland are proud to be hosting the British Blind Golf Open
Blind Golf Scotland (BGS) are proud to be hosting the British Blind Golf Open at the Macdonald Cardona Golf course from 6–10 July. BGS are pleased to be hosting international entrants from Scotland, England, Ireland, Sweden, Germany and Spain, and...
Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
Brn3b neuroprotective effect in rat glaucoma model
An adeno-associated virus-directed overexpression of the Brn3b protein in hypothesised to confer neuroprotective effects in this paper. This is ultimately tested in a well-accepted rat glaucoma model (Morrison’s model: saline injection into episcleral veins of rat eyes with a force...
Molecular genetics of achromatopsia
Achromatopsia is a rare autosomal recessive disorder of the cone photoreceptors. Typical characteristics of affected patients include the inability to distinguish colours, impaired visual acuity, photophobia and nystagmus. The condition is said to be more frequent in the Pingelapese population...
