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Retinal changes in Leber hereditary optic neuropathy

The objective of this study was to describe the changes in the retinal ganglion cell complex (GCC) relative to the retinal nerve fibre layer (RNFL) over time, in patients with Leber’s hereditary optic neuropathy (LHON). For this study, 21 patients...

Statins inhibit TGFβ2 mediated fibrotic response in astrocytes

Glaucoma is a common condition where increased ocular pressure can lead to death of retinal ganglion cells due to impaired drainage of fluid from the eye. One mechanism involved in glaucoma is remodelling of the extracellular matrix at the lamina...

Association between colour vision impairment and amyotrophic lateral sclerosis (ALS)

The purpose of this study is to test the hypothesis that colour vision impairment is associated with amyotrophic lateral sclerosis (ALS). Abnormalities of the inner and intermediate retinal structures in patients with ALS have been described using optical coherence tomography...

The clinical spectrum of albinism

The authors sought to examine clinical correlates that may be related to foveal development in albinism with an aim to qualitatively describe the phenotype spectrum of albinism. Binocular best corrected visual acuity ranged from 20/20 to 20/80. Best corrected visual...

Ocular ischaemic syndrome in a rat model

Ocular Ischaemic syndrome is a devastating eye disease caused by severe carotid stenosis. This study’s purpose was to develop a reliable rat model for this syndrome by subjecting rats to common carotid artery occlusion and sham surgery. Rats were assigned...

Avastin vs. Volon A for diabetic macular oedema

This prospective randomised interventional clinical trial compared 30 diabetic patients with macular oedema treated with either intravitreal injections of bevacizumab (Avastin) or triamcinolone (Volon A). One group initially received three injections of 2.5 mg Avastin in monthly intervals whilst the...

BV after long-standing exotropia

Pre and postoperative binocular vision (BV) was compared in long-standing large angle exo deviations. The purpose was to determine the BV potential in these cases and particularly for those at risk of postoperative paradoxical diplopia. In this retrospective study patients...

Clinical and neuro-ophthalmologic predictors of visual outcome in idiopathic intracranial hypertension

This prospective study of 40 patients aims to assess visual morbidity in patients with idiopathic intracranial hypertension (IIH). Final visual outcome of patients was compared with clinical and neuro-ophthalmic parameters such as visual acuity, visual field, contrast sensitivity, retinal nerve...

Strabismus measurement comparisons

The authors conducted a prospective study to compare the measurements obtained by objective alternate prism and cover test (PCT) and the subjective red glass test in 72 patients aged 60 years on average and with a mean visual acuity of...

Lucentis for pseudophakic CMO

Pseudophakic cystoid macular oedema (CMO) develops angiographically in up to 20-30% after uneventful phacoemulsification. This study aimed to evaluate the potential efficacy and safety of intravitreal ranibizumab in patients with pseudophakic CMO after cataract surgery. Seven eyes were included in...

Two illustrative cases of AZOOR

The authors present two illustrative cases of acute zonal occult outer retinopathy (AZOOR) which causes acute idiopathic blind spot enlargement. The disease is characterised by sudden loss of outer retinal function associated with photopsia, with minimal or no fundoscopic changes...

Retinal microvasculature in amblyopic eyes

This study evaluated and compared measurements of macular vessel density and foveal avascular zone using optical coherence tomography (OCT) angiography in amblyopia eyes and age-matched controls to determine whether results are in agreement with previous studies. This was a cross...