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Transfected RPE cells inhibit AMD in rats

Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...

Intermittent exotropia and refractive change in children

The authors present a retrospective case review with the aim of examining the relationship between refractive change and intermittent exotropia (IXT). The medical records of patients were reviewed for those aged 18 years old and younger diagnosed with IXT with...

The curse of the college museum

David Greig lecture notebook. Courtesy of Dr Jacqueline Cahif, College Archivist, Royal College of Surgeons of Edinburgh. As sure as the inevitability of death and taxes, the hidden stories of past events will intermittently rise to the surface like oil...

The Surgeon

The Surgeon is a short, fictional story based in the (very) near future, 2030. It covers the investigation of a politician who died during routine heart surgery carried out by a prominent cardiothoracic surgeon using a robotic system/AI (called A.I.R)....

Using a pupillometer to confirm presence of RAPD in post stroke homonymous hemianopia

It has been reported that relative afferent pupillary defects (RAPDs) may be present in patients with occipital lobe lesions. However, a small contralateral RAPD due to a difference in the crossed and uncrossed fibres can be difficult to detect using...

Progress in retinal disease management: Highlights of the Retina Day, RCOphth 2025 Annual Congress

The Retina Day meeting at the Royal College of Ophthalmologists (RCOphth) 2025 Annual Congress in Liverpool was held on 22 May 2025. This report highlights 10 selected topics of interest to subspecialists and general ophthalmologists. Decarbonising anti-VEGF clinics (or making...

Glaukos Launches iStent infinite® in the UK Following MDR Approval

Glaukos has announced the launch of its latest glaucoma treatment, iStent infinite®, in the UK market after securing approval under the European Medical Device Regulation (MDR). This new approval process is rigorous and provides ophthalmologists with reassurance regarding the efficacy...

Retinal prosthetics: science fiction or a vision for the future?

“Is it a fact – or have I dreamt it – that, by means of electricity, the world of matter has become a great nerve, vibrating thousands of miles in a breathless point of time?” – Nathaniel Hawthorne, The House...

Comparison of MRI finding in oculomotor cranial nerve palsies as a result of inflammation and ischaemia

This study aimed to explore the value of asymmetric enhancement of the cavernous sinus on MRI for differential diagnosis between ocular myasthenia gravis, ischemic or inflammatory oculomotor cranial nerve palsies. Three groups were recruited consecutively over a 30-month period and...

A day in the life of...an ophthalmic imager / an orthoptic assistant

The ophthalmic imager My role as an ophthalmic / medical photographer has evolved, dramatically, since I began my career at Manchester Royal Eye Hospital, 30 years ago. Long gone are the days of developing and hand printing fluorescein angiograms in...

Personalising the management of dry eye disease: TFOS DEWS III updates evidence-based recommendations

Dry eye disease (DED) is a heterogenous condition that arises from various aetiologic factors and leads to tear film instability, ocular surface damage and neurosensory changes. Symptoms of DED include ocular dryness, burning, itching, pain and visual impairment. An evidence-based...

“I can’t see nothing out of that eye, you ....!”

This is exactly the call you don’t want to receive at 11 at night. The A&E colleague phoned to inform me about a young man who was kicked several times in the face and could not see out of one...