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Test combination which could detect prodromal Alzheimer disease
The authors prospectively recruited a convenience sample of individuals aged over 65 and either with a diagnosis of mild cognitive impairment (MCI) due to Alzheimer disease or normal cognition. Other types of dementia and severe neurological conditions were excluded. All...Oculomics and Big Data changes the game for Medical Ophthalmologists
Oculomics and Big Data changes the game for Medical Ophthalmologists, and here's why.
RCT of surgery to correct asymmetrical DVD
This study compared the efficacy of two procedures: (1) bilateral symmetrical anteriorisation of the inferior oblique (AIO) and (2) combined resection and AIO, in cases of asymmetrical dissociated vertical deviation (DVD). This was a prospective randomised controlled trial including 54...
Review of international telemedicine infrastructure for ROP
This review aimed to review the information and communications technology available for telemedicine, the internet access and economic status of countries at greater risk for higher prevalence of ROP, the framework of established ROP telemedicine programmes, and the cost-effectiveness of...Moorfields: The 2025 macula course
The 2025 Macula course will take place from 2nd - 5th June 2025. Bookings are now open. Retinal diseases are a major cause of blindness. Diagnostic investigations, understanding of disease mechanisms, new therapies, and the evidence base, have all evolved...
Visual prognosis in Irish Leber’s hereditary optic neuropathy
Leber’s hereditary optic neuropathy (LHON) is an inherited optic neuropathy This paper presents a retrospective review of clinical data from patients with LHON presenting to an Irish tertiary referral ophthalmic hospital. Clinical and genetic characteristics were assessed for useful biomarkers...
Accuracy of anterior segment OCT in identifying medial and lateral recti muscle insertions in previously operated eyes
In this study, the authors aimed to assess the reliability of anterior segment optical coherence tomography (ASOCT) measurements in strabismus reoperations for locating muscle insertions. This was a prospective observational study of 30 patients (60 previously operated horizontal rectus muscles:...Landmark dataset to accelerate research on anterior segment eye disease
Diseases affecting the anterior segment, the front part of the eye, are among the leading causes of visual impairment and blindness globally, yet few large-scale datasets have been available for these conditions. In response, clinical researchers at Moorfields Eye Hospital...
Scheimpflug images and graft rejection
This study aimed to assess corneal changes using 360-degree Scheimpflug images and pachymetry readings to outline screening parameters, which define graft rejection. Seventeen eyes of 16 patients developed clinically manifest allograft rejection two to 42 months after surgery – those...
First systematic review of COVID-19 colonisation of ocular tissues and secretions
The authors present the first systematic review summarising all the data regarding SARS-CoV-2 colonisation of ocular and periocular tissues and secretions. They reviewed all publications between December 2019 to April 2020 in the Cochrane Library, Medline, World of Science and...
ROCK inhibition after descemetorhexis without endothelial keratoplasty: a small but timely Indian RCT
The authors present a single-centre, prospective, randomised, comparative clinical trial (RCT) of 24 eyes of 24 patients with mild-to-moderate Fuchs endothelial corneal dystrophy (FECD) undergoing combined phacoemulsification and a standardised 4mm central descemetorhexis without endothelial keratoplasty (DWEK), with or without...
