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Reduced blood flow and age-related macular degeneration
This was a prospective cross-sectional study assessing changes in blood flow velocity in patients with age-related macular degeneration (AMD) using a retinal function imager. Sixty eyes with wet AMD were compared to 53 control eyes and the average blood flow...
Topical doxycycline for corneal neovascularisation
Six eyes with corneal vascularisation were treated with 1% topical doxycycline, four times a day for three weeks. The patients were reviewed at various intervals over a period of one year. The eyes selected had neovascularisation secondary to a variety...
A relationship between central serous retinopathy and obstructive sleep apnoea
This prospective study aimed to evaluate a relationship between central serous retinopathy (CSR) and obstructive sleep apnoea (OSA). Twenty-three subjects (six female and 17 male) were diagnosed with CSR and overnight polysonography was performed to record desaturation and apnoeic episodes....
Autophagy in lens mitochondria loss
The lens consists of a monolayer of epithelial cells that overlies fibre cells that differentiate from epithelial cells at the equator. While developing, fibre cells need mitochondria to provide energy, as they mature they lose these and other organelles to...
Diabetic retinopathy and body fat distribution and adipokine secretion in type 2 diabetics
The major risk factors for diabetic retinopathy (DR) in patients with diabetes are poor glycaemic or blood pressure control, duration of diabetes and nephropathy related to the severity of DR. Several studies suggest that DR is associated with visceral fat...
Complement Factor H and Factor H-Like protein are expressed in human RPE cells
The role of inflammation in age-related macular degeneration (AMD) is well documented and the association of AMD with the inflammatory marker C-reactive protein (CRP) and members of the complement system underline the role of complements in AMD. Human complement factor...
Therapeutic ocular surface medium for persistent corneal epithelial defect
Corneal ulcers and persistent epithelial defects (PEDs) are caused by a variety of different insults to the cornea, which includes limbal epithelial stem cell failure. PED may be resistant to healing with standard therapy such as frequent ointments and /...
Correlation between anti-retinal antibodies and proliferative vitreoretinopathy (PVR)
The pathological basis of PVR is not clearly understood and there are no effective medications targeting this condition. This cross-sectional study looked at the possible association of anti-retinal antibodies with patients with PVR and retinal detachment (RD). Aqueous and vitreous...
Meibomian gland alteration in patients with primary chronic dacryocystitis: An in vivo confocal microscopy study
Chronic dacryocystitis affects tear film functionality and can predispose to ocular surface disease, however the specific effect of chronic dacryocystitis on meibomian gland function has not been studied. This group therefore performed in vivo confocal microscopy in 28 patients’ eyes...
Systemic rituximab immunotherapy in the management of primary ocular adnexal lymphoma single institutional experience
Ocular adnexal lymphomas constitute 2% of all non-Hodgkin’s disease and 5-15% of all extranodal lymphomas and are usually localised, low-grade and of B-cell origin. This opens them up to potential treatment with a systemic monoclonal antibody-based drug (rituximab) directed at...
Enzymatic clearance of anterior chamber infiltrate in uveitis
Aqueous humour (AH) which fills the anterior chamber (AC) of the eye provides nutrients to the cornea and the lens. Clearance of cellular and particular matter from AH is necessary for good visual acuity. In part this is achieved by...
