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Quarter DMEK
This case report describes a novel technique where one quarter of Descemet’s membrane (DM) was transplanted during a quarter-descemet membrane endothelial keratoplasty (DMEK) procedure. DMEK graft was prepared from a 58-year-old corneo-scleral donor after one week in culture. Peripheral DM...
Ovarian hormones drive onset of Sjogren’s disease in mice
Sjogren’s syndrome (SS) is a debilitating, sight-threatening, systemic autoimmune disease with no effective treatment available. SS is characterised by lacrimal gland lymphocytic infiltration and epithelial cell death, as well as by the presence of serum autoantibodies. Patients have severe dry...
Transcriptomic analysis of ocular tissues
Transcriptomics is defined as the analysis of the complete set of RNA transcripts present in a cell under different circumstances, quiescent versus challenge, by microarray analysis. Comparison of transcriptomes identifies genes that are differentially expressed in different cell populations under...
CD40L activation of human RPE cells
Age-related macular degeneration (AMD) is the leading cause of reduced visual acuity in the elderly worldwide. The risk factors involved in AMD include smoking and diet, while genetics have been shown to have a significant role. Recently a link between...
Multimodal imaging in wet AMD
This novel study set out to determine grader agreement levels of various retinal imaging techniques, commonly used in the diagnosis of wet age-related macular degeneration (AMD). Images from 52 eyes were by examined by two different observers. All images were...
Results of four years of implantation of XEN glaucoma gel stent
This multi-centred prospective, non-randomised study presents the long-term clinical outcomes in patients after implantation of transscleral XEN Glaucoma Gel Microstent, 63μm. (XEN-GGM, Allergan, New Jersey). It was conducted in Austria, Canada and Germany. Sixty-four consecutive eyes of 64 patients with...
Amblyopia prediction using Plusoptix
The aims of this study were to evaluate Plusoptix performance in amblyopia prediction, to examine the best readings for that prediction and to determine if it is sufficient to have one measure or more. Data were collected in a two-year...
Sub-clinical detection methods in multiple sclerosis
Visually symptomatic multiple sclerosis (MS) provides only part of the required information to assist in understanding the disease. Recently, researchers have concentrated their efforts on diagnosing MS cases in the subclinical period. The aim of this paper was to assess...
