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Anatomical and functional outcomes following switching from aflibercept to ranibizumab in NARMD

This is a six-month, prospective, single-arm study in the UK and Germany. A total of 100 patients were enrolled (one in the primary failure group, 99 in the suboptimal treatment response group), treated three-monthly intravitreal ranibizumab injections (0.5mg), and then...

Intravitreal Ziv-Aflibercept: safety analysis

Ziv-Aflibercept (Zaltrap; Sanofi-Aventis U.S LLS, Bridgewater, NJ) was originally introduced as an intravenous formulation for metastatic colorectal cancer. The adoption of Ziv-Aflibercept in ophthalmic practice was similar to bevacizumab, and reports have previously examined one to two year visual outcomes...

Characteristics of limbal lymphatic vasculature on confocal microscopy

This ex vivo study aims to describe the morphological characteristics of the human limbal lymphatic vasculature using confocal microscopy and immunofluorescence. Twelve corneal specimens are obtained from human donor eyes. These corneal buttons are not suitable for transplantation due to...

Correlation between aqueous flare and macular microvascular status in diabetes mellitus

The authors report a cross-sectional study which was conducted to investigate the correlation between aqueous flare and macular microvascular status, assessed by optic coherence tomography angiography (OCTA) in diabetes mellitus. Fifty-two diabetic patients with non-proliferative retinopathy, 44 diabetic patients without...

Wet AMD outcomes post cataract surgery

The authors present the findings of a retrospective study looking at the progression of wet age-related macular degeneration (AMD) in patients who underwent cataract surgery. They recruited a series of 111 patients of which 38 were men and 73 were...

Does lower eyelid entropion repair alter corneal topography?

The authors aimed to analyse the corneal morphology before and after advancement of posterior lower eyelid retractors (LERs) alone or in combination with a lateral tarsal strip (LTS) for lower eyelid involutional entropion. Retrospective analysis of 24 consecutive elderly patients...

Progression of macular atrophy on long-term anti-VEGF therapy for AMD

This retrospective study evaluated the progression of macular atrophy in 53 eyes of 53 patients receiving AntiVEGF Therapy for age-related macular degeneration (nAMD), for at least six years. None of the patients had any macular atrophy (MA) at presentation. MA...

OCT prognostic factors in AMD patients with peripapillary choroidal neovascularisation

In this retrospective study the authors aimed to investigate the correlation between optical coherence tomography (OCT) findings and visual acuity outcomes after treatment with intravitreal bevacizumab (IVB) injections for age-related macular degeneration (AMD) patients with peripapillary choroidal neovascularisation (PPCNV). Data...

Microsporidia-induced stromal keratitis: a new cause of presumed immune stromal (interstitial) keratitis

This is a non-comparative retrospective observational case series from India from 1 October 2020 to 31 January 2021. The inclusion criteria were: (1) presence of nummular / coin shaped lesions with at least one >2mm in size and / presence...

Current concepts of the uveitis-glaucoma-hyphaema (UGH) syndrome

The authors discuss pathophysiology, aetiology and current management strategies of UGH syndrome. The clinical features of UGH are different than initial descriptions. UGH today is most often associated with posterior chamber IOLs that are not placed within the capsular bag...

Tumour characteristics influencing visual field outcomes

This retrospective study aimed to explore correlations between pituitary tumour characteristics which influenced visual field changes. Cases of transsphenoidal surgery from a six-year period resulting in a pathologic diagnosis of pituitary adenoma from a single centre were identified. Individuals were...