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Injection of methotrexate into silicone oil-filled eyes for grade C PVR
Methotrexate (MTX) is an antineoplastic antimetabolite with immunosuppressant properties. Folate antagonism is known to contribute to the antiproliferative effects of MTX, and release of adenosine from cells and inhibition of polyamines may explain its anti-inflammatory effects. These activities contribute to...
Microvascular disease in Alport syndrome
The authors present the findings of a retrospective case-control observational study on increased microvascular disease in individuals with Alport syndrome recruited over a 21-year period. They recruited 28 males and 28 females with X-linked Alport syndrome (XLAS) and eight men...
Quality of life concerns after uveal melanoma diagnosis
The authors sought to investigate factors associated with Quality Of Life (QOL) after initial diagnosis of uveal melanoma (UM) using prospectively collected data between September 2011-May 2016. They included 201 participants referred for radiotherapy after UM diagnosis by an ophthalmic...
RR versus PR in children with intermittent exotropia
This is a retrospective study of 186 children who underwent resection-recession (RR) or plication-recession (PR) for intermittent exotropia between January 2008 and July 2016, from Seoul Korea, with a minimum follow-up of two years. Standard fornix based approach was used...
Atropine treatment for myopia in western countries – rationale
This preliminary study sets out the rationale, methodology and participant baseline characteristics for the Western Australia Atropine for the Treatment of Myopia (WA-ATOM). It is a double masked randomised placebo-controlled trial. This study is designed to be combined with the...
Intravitreal Ziv-Aflibercept: safety analysis
Ziv-Aflibercept (Zaltrap; Sanofi-Aventis U.S LLS, Bridgewater, NJ) was originally introduced as an intravenous formulation for metastatic colorectal cancer. The adoption of Ziv-Aflibercept in ophthalmic practice was similar to bevacizumab, and reports have previously examined one to two year visual outcomes...
Review of pathogenesis of Acanthamoeba keratitis
In this review, the author summarised the current microbiomic and immunological evidence related to the pathogenesis of Acanthamoeba keratitis (AK). AK has been described for almost 50 years, but the exact biology of the disease remains perplexing. Acanthamoeba spp. are...
Oculofacial plastic surgery – is antibiotic prophylaxis required?
This is a randomised, controlled, unmasked clinical trial evaluating whether topical antibiotic prophylaxis reduces the rate of infection after oculofacial plastic surgery compared to a non-antibiotic ointment. A total of 401 participants over the age of 18 were recruited, with...
Diagnostic accuracy of enhanced depth imaging OCT in children
The authors present the findings of a retrospective cross-sectional case series. Cases were identified using a treatment register having been evaluated in a set one-year period. Two ophthalmologists acted as masked image examiners for enhanced depth imaging optical coherence tomography...
Unique case of steroid-induced intraocular pressure spike causing NAION
The literature describes previous cases of nonarteritic anterior ischaemic optic neuropathy (NAION) following rapid rises in intraocular pressure (IOP) leading to reduced optic nerve head perfusion and disruption. This is commonly following ophthalmic procedures, acute glaucoma or steroid eye drops....
Retinoblastoma in older children
Retinoblastoma is the most common ophthalmic malignancy in childhood and over 90% are diagnosed before the age of five years. It is not often suspected in older children given its rarity and unusual clinical findings which complicates the diagnosis. The...
