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Lothian Optometry Teach and Treat Clinic
The Lothian Optometry Teach and Treat (LOTT) Clinic is a supervised training clinic for community optometrists with an interest in managing patients with acute eye pathology, normally managed in the hospital setting. LOTT, which is the first clinic of its...The last three patients: dermatology (Patient Three)
For the third and final reflection in this series (see Part 1 and Part 2), Professor Jonathan Rees recounts his experience of a patient with cancer who was failed by the NHS, and how their inadequate treatment illuminates some issues...Artificial intelligence and oculomics: Improving global health
The application of artificial intelligence (AI), and in particular deep learning, to high-resolution ocular imaging has led to many new discoveries, enabling the prediction of multiple different systemic diseases from ocular biomarkers. This emerging field is known as ‘oculomics’ [1]....Videos - iStent Inject
Trabecular bypass surgery with iStent Inject enhances aqueous outflow from the eye , evidence of this is demonstrated through Angiographic visualization of aqueous humor outflow in studies conducted by Dr. Alex Huang M.D, Ph.D
Importing iron to the retina
In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...
Prophylaxis for clinical macular oedema after phacoemulsification
The authors report on a retrospective cohort study looking at three different prophylaxis methods for macular oedema after cataract surgery: 1) Topical prednisolone acetate (PA) alone; 2) Topical PA in combination with non-steroidal anti-inflammatory drug (NSAID); 3) Intraoperative subconjunctival injection...
Intravitreal aflibercept for diabetic macular oedema
The VISTA and VIVID randomised phase 3 trial were designed to compare the efficacy and safety of intravitreal aflibercept injections versus laser photocoagulation for diabetic macular oedema (DMO). A total of 872 patients with centrally involving DMO were recruited, and...
Sustained elevation of extracellular ATP in chronic glaucoma
Although adenosine 5′-triphosphate (ATP) release from retinal neurons and astrocytes has been demonstrated in short-term increases in intraocular pressure (IOP); such as in aqueous humor of humans with primary acute angle closure glaucoma, the response in chronic IOP elevation was...
Brn3b neuroprotective effect in rat glaucoma model
An adeno-associated virus-directed overexpression of the Brn3b protein in hypothesised to confer neuroprotective effects in this paper. This is ultimately tested in a well-accepted rat glaucoma model (Morrison’s model: saline injection into episcleral veins of rat eyes with a force...
Reduced angle after BT for postop diplopia test
The authors undertook a retrospective study to evaluate the extent of reduced deviation after Botulinum toxin (BT) when used as a postoperative diplopia test. They evaluated effect in 39 patients: 32 exotropia and seven esotropia. The same BT dose was...
Infantile exotropia and developmental delay
This is a retrospective review of infants requiring surgery for infantile exotropia before the age of one year to report the surgical outcomes and frequency of associated developmental problems. The study reviewed 26 patients first assessed at two to 10...
