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In vivo confocal microscopy, principles and use in keratitis Part 1: Principles

In 1968 Maurice introduced the concept of high powered specular microscopy, it was in that very year that the first scanning confocal microscope was proposed. Marvin Minsky developed the first confocal microscope in 1955 named the ‘double focusing scanning microscope’....

Confocal microscopy and corneal graft rejection

Forty-five patients following penetrating keratoplasty (PK) were examined with the HRT III Rostock Cornea Module confocal microscope at various points after their surgery for two years. Activated keratocytes (AKs) were counted manually and their mean number evaluated. A pattern was...

Investigation into the anatomical differences of eyelashes between Caucasian and Indian specimens

This study investigated the anatomy of human eyelashes through analysis of root depth, angle, and spatial relationship. Four eyelids from Caucasian donors were obtained from fresh donors and four eyelids from Indian donors were obtained from eye bank calls. The...

An Introduction to: RCOphth's Microsurgery Course

For foundation doctors and medical students with a keen interest on becoming ophthalmologists, the RCOphth Microsurgery Introduction Course stands as a gateway to introducing doctors to the intricacies of microsurgery.

SS-MIOCT for suture depth

The authors describe a case in which swept-source microscope-integrated OCT (SS-MIOCT) was used to directly visualise and evaluate key suturing-related steps of strabismus surgery in real time. Using SS-MIOCT, the surgeons could visualise the precise depth of the needle through...

Glasgow eye department continues to disrupt ocular simulation training through novel DRV system - the first of many?

Ongoing technological developments are enabling continuous progress to be made across all aspects of medical simulation training. This is particularly true within the field of ophthalmology, where surgical training advancements have enabled the role of simulation to expand dramatically over...

Glasgow eye department continues to disrupt ocular simulation training through novel DRV system - the first of many?

Ongoing technological developments are enabling continuous progress to be made across all aspects of medical simulation training. This is particularly true within the field of ophthalmology, where surgical training advancements have enabled the role of simulation to expand dramatically over...

Meibomian gland alteration in patients with primary chronic dacryocystitis: An in vivo confocal microscopy study

Chronic dacryocystitis affects tear film functionality and can predispose to ocular surface disease, however the specific effect of chronic dacryocystitis on meibomian gland function has not been studied. This group therefore performed in vivo confocal microscopy in 28 patients’ eyes...

ARVO (The Association for Research in Vision and Ophthalmology) 2025

i3: imagining innovation and intelligence in vision science This is an incredibly exciting time in ophthalmology and vision science research. Technological innovations have allowed us to probe the workings of the eye from the microscopic to the macroscopic level with...

Characteristics of limbal lymphatic vasculature on confocal microscopy

This ex vivo study aims to describe the morphological characteristics of the human limbal lymphatic vasculature using confocal microscopy and immunofluorescence. Twelve corneal specimens are obtained from human donor eyes. These corneal buttons are not suitable for transplantation due to...

The future of binocular viewing systems?

I recently had the pleasure to visit Vision Engineering’s headquarters and manufacturing facility in Woking, UK. Vision Engineering have built an international reputation for engineering microscopes that provide 3D visualisation without the use of traditional optical eyepieces. Although the company...

Long-term specular microscopy following Nd: YAG iridotomy in chronic POAG

The aim of this study was to evaluate specular microscopy of chronic primary angle-closure glaucoma (CPACG) eyes at least one year after Nd:YAG iridotomy, and compare them with CPACG eyes without an iridotomy and age-matched, normal eyes. Nd:YAG laser causes...