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Preoperative RPE alterations in macular holes

This retrospective interventional case series from Japan assessed whether preoperative alterations of the retinal pigment epithelial (RPE) in idiopathic macular holes correlated with postoperative functional and morphological changes in the macula. Fifty-nine eyes had preoperative Spectralis OCT using the ‘detailed’...

Outcomes of corneal collagen crosslinking (CXL) in pseudophakic bullous keratopathy (PBK)

This was a retrospective non-comparative, interventional case series of 50 eyes in 50 patients with symptomatic PBK who underwent CXL (epithelium-off). Central corneal thickness (CCT), pain score, best corrected visual acuity (BCVA), and corneal transparency were recorded at baseline; at...

As Far as the Eye Can See: A History of Seeing

I am a big fan of books which provide a historical context to some of the greatest wonders and challenges that we face. Siddarhtha Mukherjee does this well in Emperor of All Maladies (2010), where he explores the story of...

Use of amniotic membrane in second stage Hughes tarsocunjunctival reconstruction

This is a retrospective, non-comparative interventional case series of 30 patients who underwent amniotic membrane transplantation to lower lid margin as part of Hughes lid reconstruction to prevent a hyperaemic, hypertrophic conjunctival margin with excessive discharge. Patients undergoing more than...

Reducing myopia progression

This paper reports a literature review to discuss the environmental considerations and treatment options that can prevent the progression of myopia, including time spent outdoors, reduction of near vision activities, spectacle types, contact lens type and pharmacological treatment. The review...

Orthoptic Cochrane reviews

The purpose of this study was to explore the Cochrane Eyes and Vision (CEV) library to extract and overview protocols and systematic reviews of relevance to orthoptic practice. A full database search was made of the 2016 library. Twenty-seven systematic...

One-year result of XEN45 implant for glaucoma: efficacy, safety, and postoperative management

The authors report a retrospective, non-randomised interventional case series of 39 patients who underwent a standalone XEN45 implantation. All 39 patients (female: male=1.2: 1) completed 12-month follow-up. Mean age was 70.1 years (range 32–92). Primary outcome measures were the intraocular...

An educational intervention to improve adherence to high-dosage patching regimen for amblyopia

This is a randomised trial of patients recruited between the periods of March 2006 and March 2008 from ophthalmology clinics in the Leicestershire area. A total of 62 children with newly diagnosed amblyopia were allocated randomly into two treatment arms...

Leber’s hereditary optic neuropathy: from lab to clinic

Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...

Incomplete teprotumumab treatment for thyroid eye disease

This is a multi-centre retrospective analysis of clinical outcomes in patients who were on teprotumumab for thyroid eye disease but had the usual regime of eight infusions, three weeks apart, interrupted due to COVID-19. Manufacturing was suspended between Dec 2020...