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Systemic pharmacology of intravitreal anti-VEGF
This study aimed to evaluate and compare serum drug concentrations and plasma free-VEGF concentrations in patients with AMD, DME, or RVO receiving intravitreal injections of aflibercept, bevacizumab or ranibizumab. This prospective study enrolled patients from several offices of a single...
Aqueous humour cytokine levels in PCV and nAMD
This study looks into the possible roles of various cytokines or growth factors in the pathogenesis of exudative age-related macular degeneration (AMD) by comparing aqueous levels of 14 cytokines between eyes with polypoidal choroidal vasculopathy (PCV) and those with neovascular...
Intravitreal dexamethasone implant for diabetic macular oedema
The authors report on the three-year outcomes of the Ozurdex Dexamethasone (DEX) intravitreal implant multi-centre trial for the treatment of diabetic macular oedema (DME). Patients with DME (best-corrected vision of 20/50 to 20/200 and central retinal thickness of ≥300µm) were...
Comparison of ketorolac 0.4% and nepafenac 0.1% for the prevention of CMO after phacoemulsification
This is a prospective randomised clinical trial study including patients older than 40 years with age related cataract and normal ophthalmic examination. The patients are randomised into three different groups and the objective of the study is to compare the...
Moxifloxacin 0.5% for bacterial keratitis
The authors report on the results of a randomised controlled trial comparing commercially available non-preserved moxifloxacin 0.5% vs. a combination of fortified cefazolin 5% and tobramycin 1.3% in the treatment of moderate bacterial keratitis without perforation. Corneal scrapings were collected...
Long-term results of cross-linking treatment for keratoconus
The authors report on the long-term outcomes in a prospective case series of patients with keratoconus undergoing corneal collagen cross-linking (CXL) treatment. Thirty-two patients (40 eyes; mean age 22.5+/-5.5 years) with Grade I, II and III progressive keratoconus were recruited...
Metamorphopsia in idiopathic epiretinal membranes
The Amsler grid is commonly used for self-monitoring, but is qualitative and has low sensitivity. The M-chart reduces the amount of spatial redundancy (‘filling in’) in the Amsler grid. The Orientation Discrimination (OD) test studied in this paper consists of...
Results of four years of implantation of XEN glaucoma gel stent
This multi-centred prospective, non-randomised study presents the long-term clinical outcomes in patients after implantation of transscleral XEN Glaucoma Gel Microstent, 63μm. (XEN-GGM, Allergan, New Jersey). It was conducted in Austria, Canada and Germany. Sixty-four consecutive eyes of 64 patients with...
Retinoblastoma risk factors for recurrence
This study evaluates risk factors for local tumour recurrence of main solid tumour, subretinal seed, vitreous seed and new tumour formation in eyes with retinoblastoma (RB) management with primary chemotherapy over 20 years of follow-up. The study included 960 eyes...
Mobile phone use with esotropia development
This study analysed clinical characteristics and surgical outcomes in patients with acquired comitant esotropia (ACET) and determined the prevalence of excessive mobile touch screen device use in these patients. This was a retrospective study of 35 patients of which three...
Changes in corneal endothelial layer after strabismus surgery
The purpose of this study was to investigate the changes in the corneal endothelial layer by specular microscopy after surgery in patients with horizontal and oblique strabismus. Eighty-three eyes of 56 patients were evaluated prospectively. There were three subgroups: one...
