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599 results found

RPE use similar pathway to regulatory T cells to inhibit immune response

Retinal pigment epithelial (RPE) cells form an important part of the blood-retinal barrier that protects the neuronal cells responsible for sight. RPE cells are involved in innate and adaptive immune responses via expression of surface molecules and release of cytokines....

MicroRNA mediate retinoblastoma signal transduction

MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...

Diagnosis and management of orbital vascular malformations

This is an authoritative review of a controversial and difficult clinical area. The authors have experience of over 350 cases and provide a well-structured review of the classification and management of orbital vascular malformations. They emphasise the need to understand...

Correlation between anti-retinal antibodies and proliferative vitreoretinopathy (PVR)

The pathological basis of PVR is not clearly understood and there are no effective medications targeting this condition. This cross-sectional study looked at the possible association of anti-retinal antibodies with patients with PVR and retinal detachment (RD). Aqueous and vitreous...

Enzymatic clearance of anterior chamber infiltrate in uveitis

Aqueous humour (AH) which fills the anterior chamber (AC) of the eye provides nutrients to the cornea and the lens. Clearance of cellular and particular matter from AH is necessary for good visual acuity. In part this is achieved by...

Macular pigment and dark adaptation in older population with normal maculas

Macular pigment (MP) such as lutein, zeaxanthin and meso-zeaxanthin are highly concentrated in the fovea. They protect the retina from damage of ambient blue light via antioxidant properties. In older eyes with normal healthy retina, macular pigment optical density (MPOD)...

Using graphical illustration to predict giant cell arteritis

A nomogram is a chart or graph of scaled variables that facilitates the approximate computation of a mathematical function via intersecting lines. The objective of this study was to illustrate the use of a nomogram for the prediction of giant...

CD73 in aggressive basal cell carcinoma

This is a retrospective review looking at levels of CD73 in aggressive basal cell carcinomas (BCCs) that invade the orbit. Eleven patients who underwent orbital exenteration for invasion by BCCs were compared with 10 matched controls who had simple nodular...

Infection prophylaxis and first visit timing for strabismus surgery

The authors undertook this study to characterise the practice patterns of paediatric ophthalmologists regarding their use of infection prophylaxis and timing of the first postoperative visit after strabismus surgery. A 10-question multi-choice questionnaire was circulated via American Association for Pediatric...

Profile of sports-related ocular trauma

The authors conducted a previous study on the epidemiology of sports-related ocular trauma in Quebec. In this study they aim to gather further information on presentation via ophthalmology and emergency departments. They undertook a follow-up study from a tertiary care...

Orbital cavernous haemangiomas

This is a review of orbital cavernous haemangiomas (orbital cavernous venous malformations) managed over a 12-year period at a tertiary referral centre. Painless proptosis was the commonest presentation. One hundred and sixty-four patients (96 female and 68 male) underwent surgery...

A survey of neuro-ophthalmologists on use of corticosteroids in giant cell arteritis

While corticosteroids are the mainstay of treatment in giant cell arteritis (GCA), the type, dose, route and duration of treatment remains controversial. The authors surveyed 180 neuro-ophthalmologists on their use of this treatment via email in a two-month period. Results...