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A phase 3 randomised trial of nicotinamide for skin cancer chemoprevention
To B3, or not to B3? That was the question asked in this controlled trial in which the authors were able to show that oral nicotinamide (vitamin B3) is able to reduce further skin cancer development in high risk patients....
Three years of experience with quantiferon-TB Gold Testing in patients with uveitis
Quantiferon-TB Gold is a new alternative to the tuberculin skin test that utilises synthetic peptides representing M. tuberculosis antigens ESAT-6, CFP-10, TB7.7 and upon incubation with whole blood IFN-γ is released from pre-sensitised T cells and can be measured by...
Ocular Trauma Scores in paediatric open globe injuries
This is a retrospective case series of 71 open globe injuries in children of less than 18 years of age, with a minimum follow-up period of one year, between 1 September 1992 to 31 July 2011, from the Eye Department...
OCTA and pigment epithelium detachments
Yannuzzi et al. report on their study aiming to evaluate the ability of optical coherence tomography angiography (OCTA) to differentiate vascularised from nonvascularised pigment epithelium detachments (PEDs) using conventional imaging techniques, including fundus fluorescein angiography (FFA) and indocyanine green (ICG),...
Injection of methotrexate into silicone oil-filled eyes for grade C PVR
Methotrexate (MTX) is an antineoplastic antimetabolite with immunosuppressant properties. Folate antagonism is known to contribute to the antiproliferative effects of MTX, and release of adenosine from cells and inhibition of polyamines may explain its anti-inflammatory effects. These activities contribute to...
Sutureless, scleral fixated-IOLs
This was a retrospective cohort study of 112 sutureless, scleral-fixated posterior chamber intraocular lens implantations (SSFCIOL) over a four-year time period. Mean follow-up duration was 13.0 ±10.4 months. The primary indication for SSFCIOL was dislocation of IOL due to zonular...
How does low-concentration atropine reduce progression of myopia?
This is a double-blind, randomised, placebo-controlled trial evaluating the effects of low-concentration atropine (0.05%, 0.025%, 0.01%) on ocular biometrics of myopic children. The aim is to determine what aspect of ocular biometrics low-concentration atropine influenced in reducing the progression of...
Uveitis‐Glaucoma‐Hyphaemia syndrome retrospective case-control study
The authors present the findings of a case-control study aiming to assess uveitis‐glaucoma‐hyphaemia (UGH) syndrome, focusing on the resolution, glaucoma development and risk factors. The authors compared three groups each containing 71 patients. Each group contained patients with UGH syndrome,...
Detection of post stroke visual impairment in variety of cohorts
The Impact of Visual Impairment after Stroke (IVIS) study introduced a standardised vision assessment protocol across three acute stroke units in the northwest of England, with a similar demographic population (predominantly white British). The study reported similar rates of visual...
Key research and practical information to inform INS care
This ‘tutorial’ format paper aims to translate key research findings and conclusions into practical terms, discuss their clinical utility and introduce a new clinical method that accurately measures the static visual deficits in infantile nystagmus (INS), predicts the improvements that...
BT outcomes for accommodative esotropia
The purpose of this study was to study the effect of Botulinum Toxin (BT) in refractive and non-refractive accommodative esotropia unresponsive to glasses and poor compliance with glasses. This was a retrospective study of 114 patients who had BT for...
