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The compendium to clinical evidence in DMO treatment
This review article summarises the current evidence base in the treatment options for diabetic macular oedema (DMO). The authors have included many real-world data studies that provided valuable insights into the optimal management of DMO. The authors argue that these...
Is thrombolytic treatment warranted for central retinal artery occlusion?
Central retinal artery occlusion (CRAO) is a subtype of acute ischaemic stroke which results in severe visual loss. Acute CRAO is equivalent to a brain acute ischaemic stroke (AIS), as the obstruction of the central retinal artery (CRA) causes end-organ...
Outcomes of cataract surgery in patients with uveitis
This is a systematic, evidence-based literature review and meta-analysis, looking at the visual outcomes (vision 20/40 or better) of cataract surgery in uveitic eyes. The authors searched MEDLINE, EMBASE, CINHAL and CENTRAL, including English language and human studies only. They...Danger Zone: Miles Hilton-Barber
“Life is either a daring adventure, or nothing at all” – Helen Keller, deafblind American author, activist, and disability rights advocate I have always had a thirst for adventure, even if it has been predominantly from the comfort of my...PACK-crosslinking for infectious keratitis
Corneal cross-linking with riboflavin and UV-A light (CXL) is a technology that has been initially developed to treat corneal ectatic disorders [1]. Its effect in stabilising diseases such as keratoconus was reported in numerous trials with excellent long-term outcomes and...
Topical atorvastatin for dry eye and blepharitis
Dry eye is a very common problem with 20% of the population affected and is frequently associated with blepharitis (DEB), which has an over prevalence of about 40%. The aim of this study was to evaluate a topical atorvastatin formulation...
Cytotoxic effect of voriconazole on human corneal epithelial cells
Voriconazole is a second-generation synthetic derivative of fluconazole with broadened antifungal spectrum. It is becoming the drug of choice for fungal keratitis. Voriconazole eye drops are not available commercially, thus have to be prepared by diluting the intravenous formulation containing...
The long-term effects of AREDS on AMD progression
The Age-Related Eye Disease Study (AREDS) was an 11-centre, double-masked, clinical trial that in 2001 found a high-dose of antioxidant vitamins plus zinc was effective in protecting against progression of age-related macular degeneration (AMD) in patients with moderate to high...
Brolucizumab in age-related macular degeneration, HAWK Study
The aim of the study was to collect additional data on efficacy and safety of brolucizumab 6mg intended for commercialization in age-related macular degeneration (AMD) (with an increase in pH and decrease in polysorbate concentration). The HAWK Study was a...Ophthalmic entrepreneurship: Reflections from an ophthalmic surgeon
For many ophthalmic trainees and newly appointed consultants, the idea of medical entrepreneurship can feel distant and sometimes uncomfortable. We are trained in a profession centred on patient care, ethics and service. The word entrepreneur, by contrast, often brings to...Streamlining cataract lists: how are you managing it?
Mr Jonathan Ross, in conversation with Ms Bita Manzouri, provides a personal perspective on challenges and opportunities shaping the future of cataract surgery services across the hospital eye service. Redesigning cataract pathways in response to COVID-19 Bita Manzouri: Over the...
