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HtrA1 enhances cell senescence
A genetic basis for age-related macular degeneration (AMD) has been greatly advanced in recent years. The role of identified pathways such as complement factor H in AMD has been widely investigated. However, the effect of other gene variants identified by...
Nanoparticle administration of latanoprost
Glaucoma is a progressive optic neuropathy characterised by increased ocular pressure and loss of retinal ganglion cells. Conventional drug therapy with eye drops to reduce intraocular pressure (IOP) has variable bioavailability and can lead to ocular surface disease. In this...
Correlation between peak intraocular pressure following water drinking test and pulsed methylprednisolone therapy
Steroids have long been known to cause increased intraocular pressures (IOP) in susceptible patients. Intravenous methylprednisolone is used to treat many rheumatological conditions and one of the risks is raised intraocular pressure. It would be useful to find patients at...
IgG4-related disease or Graves orbitopathy
This is retrospective review of patients who had been diagnosed with both IgG4-related ophthalmic disease (IgG4-ROD) and Graves orbitopathy over a four year period. Eight patients were identified. The diagnosis of IgG4-ROD was based on 10 or more IgG4+ plasma...
How are pigment dispersion syndrome and pigmentary glaucoma inherited?
This single centre prospective, cross-sectional study assessed the relatives of patients with pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) to determine the heritability of these conditions over an 11 month period. One hundred and one unrelated patients with PDS...
Subconjunctival anaesthesia in vitreoretinal surgery
The authors present a technique that combines topical and subconjunctival anaesthesia for vitreoretinal surgery. In this ‘two-step’ procedure, three drops of proparacaine were applied to the conjunctival fornix, followed by subconjunctival lidocaine injected in three quadrants. This was compared with...
Spot screener versus Grand Seiko measurements
The authors aimed to determine repeatability and reproducibility of refractive values and pupil size measured using the Spot Vision Screener and to compare its measurement values with the Grand Seiko autorefractor. This was a cross-sectional study of 22 healthy adults;...
Use of group consultations in the management of idiopathic intracranial hypertension
The incidence of idiopathic intracranial hypertension (IIH) has risen by >100% between 2002 and 2016 in the UK, in association with rising obesity rates. This increasing incidence has inevitably led to increased pressures on service capacity. Evidence for other conditions...
Long-term use of botulinum toxin for hemifacial spasm and blepharospasm
The authors conducted a retrospective review of clinical / procedure documentation for consecutive blepharospasm (BEB) and hemifacial spasm (HFS) patients undergoing treatment with onabotulinum toxin A (Botox) in one clinic setting over the past 20 years. They report on the...
Malpractice from telephone triage in ophthalmology
The authors examined malpractice lawsuits related to ophthalmology telemedicine telephone triage in the US. The study reviewed a total of 510 lawsuits and identified 18 cases that involved synchronous telephone visits, while none involved video telecommunication. The study found that...
RetCam use in differential diagnosis for retinoblastoma
The authors aimed to evaluate RetCam fundus photography and fluorescein angiography (FA) findings in pseudo retinoblastoma. This was a retrospective review of 36 eyes of 28 patients (of which six were female) with 22 bilateral cases. Mean age at presentation...
