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Melphalon treatment of retinoblastoma

The purpose of this study was to report the authors’ experience with superselective ophthalmic artery infusion of Melphalon (SOAIM) for the treatment of five cases of unilateral sporadic retinoblastoma involving the macula. Standard therapy included a cycle of three infusions...

Reduction of severe visual loss and complications following IAC for RB

This was a retrospective cohort study of patients with retinoblastoma (RB) who required intra-arterial chemotherapy (IAC) between 2013 and 2015, who had relapsed following systemic chemotherapy. A total of nine patients were included in the study and their ocular complications...

HtrA1 enhances cell senescence

A genetic basis for age-related macular degeneration (AMD) has been greatly advanced in recent years. The role of identified pathways such as complement factor H in AMD has been widely investigated. However, the effect of other gene variants identified by...

Prevalence of strabismus in neurofibromatosis type 1

The purpose of this study was to evaluate the prevalence of strabismus in NF1 by comparing children with normal neuroimaging to those with optic pathway glioma. The study included 236 children with NF1, of which 38 were excluded with no...

Diffuse lamellar keratitis

This study group reviewed cytokine- and chemokine-mediated mechanisms of diffuse lamellar keratitis (DLK) after lamellar corneal surgical procedures. DLK can occur early or late (months to decades) after all lamellar corneal surgeries, including laser in situ keratomileusis, small incision lenticule...

Ocular adnexal marginal zone b-cell lymphoma

This is a multicentre retrospective study of seven eye centres of 689 patients with ocular adnexal extranodal marginal zone b-cell lymphoma (OA-EMZL). The median follow-up time was 42 months and the median age was 62 years. Fifty-five percent were women;...

Sebaceous gland carcinoma

This is a review of 241 patients diagnosed with periocular sebaceous gland carcinoma which investigates whether age at presentation influences either the clinical presentation or the outcomes of treatment. Twelve percent of patients were classified as young (<40 years old),...

How a paediatric population presented with diplopia

The authors present the results of a retrospective records review of 244 children presenting with diplopia over a three-year period. The majority of cases presented to paediatric ophthalmology clinic; other routes of presentation included eye casualty, neuro-ophthalmology or another eye...

Adjuvant radiotherapy in orbital malignancy

This is a retrospective review of high dose volumetric modulated arc radiotherapy (VMAT) for adjuvant treatment of patients with orbital malignancy who had already undergone local excision or exenteration. VMAT differs from conventional external beam radiotherapy in that it is...

Profile of paediatric cranial nerve palsies

The purpose of this study was to retrospectively assess the aetiology of paediatric ocular cranial nerve palsies (CNP) using neuro-ophthalmic data from three hospitals. The study included 1263 patients aged <18 years suspected of having strabismus, from January 1999 to...

Ocular adnexal mantle cell lymphoma

In this study the authors compare primary ocular adnexal (OA) mantle cell lymphoma (MCL) with initially systemic MCL occurring over a 30-year period. MCL is a rare form of lymphoma accounting for 5-11% of OA lymphomas and therefore knowledge of...

Features of childhood cases of sixth nerve palsy

Based on limited information available for cranial nerve palsies in children, the authors aimed to collect data on new onset paediatric sixth nerve palsies in a UK population. This was a retrospective study over 10 years for children aged <18...