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2552 results found

Long-term effect of gene therapy on Leber’s congenital amaurosis

After reporting the first successful gene therapy results for RPE65 deficiency in three patients in a brief report in 2008, the same team from London now report the results of 12 patients followed up for three years after transfection. As...

OCT measurements of eye muscles for Grave’s disease

The purpose of this study was to use optical coherence tomography (OCT) to assess horizontal rectus muscle thickening in patients with active and inactive Grave’s ophthalmopathy (GO) compared to healthy controls. This was a cross section observation study of rights...

Ptosis procedure compared to upper blepharoplasty on dry eye syndrome

In this prospective, comparative case series, the authors compare the effect of combined blepharoplasty and Muller muscle conjunctival resection (MMCR) to an upper blepharoplasty in dry eye syndrome. The study was approved by the local institutional review board and participants...

Silicone oil in rhegmatogenous retinal detachment

Silicone oil (SO), used in complicated retinal detachments, is associated with complications such as cataract, increased intraocular pressure (IOP), keratopathy, cystoid macular oedema (CMO), epiretinal membrane (ERM) and loss of vision. Emulsification of oil can also lead to migration of...

CHARGE syndrome features

CHARGE syndrome (CS) includes coloboma, heart defects, atresia of the choanae, retardation of growth and development, genital and urinary anomalies and ear anomalies. The authors developed an original self-administered questionnaire (VISIOcharge) for patients with CS and used it to evaluate...

Effects of ‘inverted U method’ Nd:YAG laser posterior capsulotomy on anterior segment and IOL tilt

The study aimed to investigate the effects of the ‘inverted U method’ Nd:YAG laser posterior capsulotomy on anterior segment parameters, decentration and tilt of intraocular lens (IOLs) and visual acuity in 76 patients with posterior capsular opacification (PCO) after previous...

Frontalis muscle flap for congenital ptosis

This is a review of 43 patients (47 eyes) with severe congenital ptosis who underwent a suspension procedure using a frontalis flap technique. The average age of patients was 6 +/-2.5 years, and all had a severe ptosis with an...

Treatment and outcomes for Peters anomaly (PA)

The purpose of this study was to evaluate the experience of patients with Peters anomaly (PA) and their treatment results. The study reviewed records of 27 patients (32 eyes); 74% male. Treatment included medical follow-up, optical iridectomy and penetrating keratoplasty...

Exploring the potential of neurodegenerative disease screening within age-related eye disease research

The authors recruited healthy controls aged between 60 and 75-years-old, previously enrolled into a registry as patients following cataract surgery without age-related macular degeneration (AMD). Exclusion criteria included dense cataract, retinal disease, ocular inflammatory disease, moderate glaucoma, optic neuropathy, cancer,...

Did the COVID-19 pandemic affect quality of life of patients newly diagnosed with intra-cranial hypertension?

Coronavirus disease 2019 (COVID-19) was identified as a global pandemic by the World Health Organization in March 2020. This article aimed to explore how the care of patients with idiopathic intra-cranial hypertension (IIH) was affected during the COVID-19 lockdown. The...

Current concepts of the uveitis-glaucoma-hyphaema (UGH) syndrome

The authors discuss pathophysiology, aetiology and current management strategies of UGH syndrome. The clinical features of UGH are different than initial descriptions. UGH today is most often associated with posterior chamber IOLs that are not placed within the capsular bag...

PRPF31-related retinitis pigmentosa and asymptomatic carriers

The authors present a study of 21 patients with variants in the PRPF31 gene classified as pathogenic or likely pathogenic. These variants are caused by autosomal dominant retinitis pigmentosa (RP-11). Between January 2020 and November 2021 patients underwent tests of...