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Leber’s hereditary optic neuropathy: from lab to clinic

1 October 2016 | | EYE - Neuro-ophthalmology | Hereditary optic neuropathy, Leber hereditary optic neuropathy, mitochondrial optic neuropathy, optic neuropathy
Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...

Intravitreal afibercept and ranibizumab for PCV

1 August 2016 | | EYE - Vitreo-Retinal
This is a retrospective, interventional series comprising 98 eyes with polypidal choroidal vasculopathy (PCV) with the aim of comparing treatments with afibercept and ranibizumab, highlighting any differences in their efficacy. Case notes and imaging (FFA / ICG / OCT) were...

What effects do repeated Ozurdex implants have in paediatric uveitis?

1 April 2016 | | EYE - Paediatrics, EYE - Strabismus
The aim of this retrospective study was to assess the anatomical and functional results, as well as complications of repeated Ozurdex intravitreal implants in a paediatric (non-infectious) uveitis cohort. Twenty-two eyes (16 patients) received 35 Ozurdex implants over a six...

Efficacy of intravitreal dexamethasone implant in patients with persistent macular oedema

1 December 2014 | | EYE - Vitreo-Retinal
Chronic cystoid macular oedema (CME) can develop secondary to various pathologies such as diabetic maculopathy, retinal vein occlusion and uveitis. It can cause significant visual impairment and macular damage. The therapeutic effect of corticosteroids in CME is through one or...

Clinical trial investigates ‘Light Touch’ approach to wet AMD treatment

20 October 2025 | NIHR, Treatment, Retina, neovascularisation, vision
A clinical trial led by NIHR Moorfields Clinical Research Facility will explore a new ‘light-touch’ treatment approach for patients with neovascular age-related macular degeneration (wet AMD) that could result in fewer injections and reduced number of clinic visits. Funded by...
Ophthalmologica journal front cover image.

Intravitreal Aflibercept (IVT-AFL): treatment of macular oedema secondary to RVO

2 December 2025 | | EYE - Vitreo-Retinal
This paper is a sub-group analysis of the real-world effectiveness, treatment patterns, and safety of IVT-AFL in patients with macular oedema secondary to retinal vein occlusion (RVO) in Italy. One hundred and fifity-two treatment-naïve and 50 pretreated patients were enrolled...

Making sense of the orthoptic assessment

1 April 2020 | | EYE - Cataract
Following the Specialty Trainee article on this topic in the February/March 2020 issue, Joe Smith provides a more detailed breakdown of the orthoptic report. Orthoptists investigate, diagnose and manage a wide variety of patients with varying problems. In this article,...

Sexually transmitted conjunctivitis – the REALLY sticky eye

5 October 2020 | | EYE - Cornea, EYE - General
Let’s face it, patients with conjunctivitis don’t always produce the most stimulating consultations and most of the time we can manage them in auto-pilot. The prospect of delving into such a patient’s sexual history is not overly appealing, but this...

Informed consent in ophthalmology care in the UK: A critical component of patient‑centred practice

2 April 2025 | | EYE - General
Informed consent is a cornerstone of ethical and legal practice in healthcare, particularly in fields like ophthalmology where specialised interventions can have significant implications for a patient’s vision and quality of life. In the UK, informed consent is not merely...

Mastering clinical skills in ophthalmology

3 October 2022 | | EYE - General
To young junior doctors, and some senior doctors who may not have had much exposure to ophthalmology, the specialty can seem very foreign. Not only are the conditions and examination findings specific to the eyes, but the skill set required...

The lived experience of benign essential blepharospasm

4 December 2025 | | EYE - Oculoplastic
Benign essential blepharospasm (BEB) is a rare neurological condition which causes involuntary sustained or intermittent muscular contraction of both eyelids and upper facial muscles which cause closure of eyelids, abnormal facial expressions and distress [1]. The term dystonia is an...

Launch of the Diabetic Retinopathy Screening Service in UHWI Jamaica

1 June 2016 | | EYE - Vitreo-Retinal
At 2.55pm on Wednesday 16 March 2016 the first patient was screened and given her results in the new nurse-led Diabetic Retinopathy Screening (DRS) Clinic at the University Hospital of the West Indies (UHWI), Kingston, Jamaica. This was the result...