You searched for "genetics"
HtrA1 enhances cell senescence
1 December 2013
| Graham Wallace
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EYE - Vitreo-Retinal
A genetic basis for age-related macular degeneration (AMD) has been greatly advanced in recent years. The role of identified pathways such as complement factor H in AMD has been widely investigated. However, the effect of other gene variants identified by...
Evaluation of ectopia lentis et pupillae (ELP)
The ADAMTSL4 gene encodes proteins for cellular adhesion, angiogenesis, nervous system development and anterior / posterior segment structures. This case report describes a four-year-old female with diagnosis at referral of ELP. A three-generation pedigree was obtained and was negative for...
Why is there subretinal fluid at the macula?
3 June 2021
| Zhihang Cheng
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EYE - Vitreo-Retinal
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Central serous chorioretinopathy (CSC), Differential diagnosis, Retinal disease, Serous fluid accumulation, Serous maculopathy
This is a review article looking at the differential diagnosis of subretinal fluid in the macula that could be diagnosed as central serous chorioretinopathy (CSCR). The authors have categorised them into 12 groups: neovascular diseases, vitelliform lesions, inflammatory diseases, ocular...
Second primary tumours after sebaceous carcinoma
This is a study investigating the risk of developing a second primary malignancy in patients previously diagnosed with eyelid sebaceous cell carcinoma. The records of 559 patients who were diagnosed with sebaceous cell carcinoma between 2000 and 2016 were reviewed,...
Human leucocyte antigen association of patients with Stevens-Johnson syndrome in Han Chinese
This is a retrospective study of the human leucocyte antigen (HLA) polymorphism pattern of cold medicine-induced patients with Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) (n=33) and 98 control patients recruited between 2016-2017 in Taiwan. Severe ocular complications (SOC) was...
Ocular findings in children with myasthenia
This is a retrospective audit of paediatric myasthenic patients presenting to Great Ormond Street (GOSH) between January 2016 and January 2020. During this period there were 49 children, including 27 with juvenile myasthenia (JMG) and the rest as congenital myasthenia...
Using a tumour registry to investigate optic nerve gliomas
31 October 2023
| Lauren R Hepworth
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EYE - Neuro-ophthalmology
This study is a retrospective comparative analysis. Patients with optic nerve glioma and pilocytic astrocytoma were identified through the Surveillance, Epidemiology and End Results (SEER) cancer registry covering a 42-year period using standardised codes. The following data was extracted: basic...
Discussing treatment modalities for bilateral wet AMD
1 December 2014
| Marie Tsaloumas, Bushra Mushtaq
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EYE - Vitreo-Retinal
A 65-year-old lady with bilateral wet AMD and vision of 6/24 comes with an internet search about current therapies. How do you explain the various treatment modalities available? There are two NICE approved treatments for wet age-related macular degeneration (AMD)....
An interview with Professor John Forrester
2 December 2019
| Hari Kaneshayogan
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EYE - General
What made you choose ophthalmology as a career and how did your interest in academia develop? During Medical School at Glasgow University, I was getting progressively disillusioned with the career options while my colleagues and friends all seemed to quickly...
In conversation with John Forrester
2 December 2019
| Hari Kaneshayogan
|
EYE - General
What made you choose ophthalmology as a career and how did your interest in academia develop? During Medical School at Glasgow University, I was getting progressively disillusioned with the career options while my colleagues and friends all seemed to quickly...
The work of BIPOSA
4 December 2023
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EYE - Paediatrics, EYE - Strabismus
The British and Irish Paediatric Ophthalmology and Strabismus Association (BIPOSA) was set up in 2008 to merge two streams of ophthalmology, namely the practice of paediatric ophthalmology and the practice of strabismus (to include refracting in children, and strabismus in...
Insights from the ‘Rb-NET Challenges’ Session: Evolving approaches in global retinoblastoma management
2 April 2025
| Mattan Arazi, Ido Didi Fabian, Nick Astbury, Brenda Gallie (Prof), Covadonga Bascaran, Marcia Zondervan
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EYE - Paediatrics, EYE - Pathology, EYE - Oncology
The Retinoblastoma Network (Rb-NET) Multidisciplinary Team (MDT) platform, developed by the London School of Hygiene & Tropical Medicine (LSHTM) and Professor Ido Didi Fabian, is a web-based telemedicine initiative that regularly hosts virtual MDT meetings focused on the evaluation and...
