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RCT of operative routes for congenital cataract surgery
The authors evaluated the performance of 25G vitrectomy systems in the management of congenital cataract in infants through two routes – anterior (transcorneal) and posterior (pars plana). This was a prospective randomised trial (RCT) of 24 eyes of 12 patients...
MicroRNA mediate retinoblastoma signal transduction
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
Glasses or not?
In this excellent review article, the authors discuss how some hyperopes avoid strabismus but also ask why the youngest infants escape strabismus and older patients go on to decompensate. The review considers a number of related aspects and their inter-relations...
Paediatric enucleation in a tertiary eye centre in North China, 2001-2015
The authors review the demography and aetiology of paediatric enucleation over a 15-year period. A total of 9307 paediatric ophthalmic inpatients ranging from 0 to 14 years who underwent surgery at Shandong Eye Institute over the past 15 years were...
Review of the use of amniotic membrane in restrictive strabismus
This literature review was undertaken to investigate the indications, complications and final results of amniotic membrane (AM) transplantation in ocular motility restrictions. The review (of 1103 papers) outlines the healing process plus use of AM. Excluded papers were those of...
Cataract progression after Nd-YAG laser iridotomy in primary angle-closure suspect eyes
A total of 889 of eligible bilateral primary angle-closure suspect (PACS) patients were recruited from the Zhongshan Angle Closure Prevention Trial. One randomly selected eye received laser peripheral iridotomy (LPI), while the fellow remained untreated. Cataract was graded by the...
The expanding spectrum of idiopathic intracranial hypertension
This is a review article from a tertiary centre in Atlanta, US. With rising obesity rates and increasing access for MRI scans there has been a large increase in patients requiring an urgent papilloedema check with incidental findings on MRI...Ophthalmology history and examination – a guide for medical students
*First author Students have very little exposure to ophthalmology during their years at medical school. Teaching consists of a handful of lectures followed by a short placement in which students are expected to practise histories and examinations on patients with...Regulatory drug evaluations and expedited review initiatives: EU and US perspectives
The European Medicines Agency (EMA) and United States Food and Drug Administration (FDA) each conduct independent assessments of benefit-risk profile when evaluating applications to market new or modified medicines, and their respective decision-making is guided by distinct legislation, procedures and...Does beauty truly lie in the eye of the beholder?
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are based on facts and which are ‘fake news’. Headline: Does beauty truly lie in the eye of the beholder? Scleral whitening, iris colour-changing drops and...
