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The fragile p-value

5 October 2020 | | EYE - General
Abdus Samad Ansari explores the limitation of the p-value and the application of the fragility index in clinical trials. Clinical trials and tribulations? The restoration of vision or more purely the gift of sight is an aspect of care that...

Understanding vasoproliferative retinal tumours

4 February 2021 | | EYE - Vitreo-Retinal, EYE - General
Syed Irtiza Ali Shah explores this rare and unusual condition through a fascinating case presentation. Vasoproliferative tumours of the retina (VPTR) are a vascular mass with an associated exudative retinopathy alongside the presence of minimally dilated feeder vessels. This is...

Proning and the pandemic - ocular complications seen in critical care

6 April 2021 | | EYE - Vitreo-Retinal, EYE - Orbit, EYE - Cornea, EYE - General
Priyanka Sanghi and her co-authors explore the ocular complications seen in critical care units throughout the country as we treat patients through this challenging time. The SARS-Cov-2 (COVID-19) pandemic has placed the NHS and critical care services under immense strain,...

Watch your back: Ergonomics and Ophthalmology

2 August 2022 | | EYE - General
Aadil Hussain discusses an ophthalmologist’s risk of musculoskeletal injury and highlights the importance of ergonomics education, to ensure a pain-free career. Chronic and disabling musculoskeletal injury has been identified in the field of ophthalmology with increasing prevalence. The ophthalmologist is...

Clinical relevance of the anatomic classification of neovascular age-related macular degeneration

1 February 2018 | | EYE - Imaging, EYE - Vitreo-Retinal
The author explains why an OCT-based classification of neovascular AMD is needed and how these neovascular subtypes may help to predict patients’ long-term visual outcome. Age-related macular degeneration (AMD) is a chronic and progressive neurodegenerative process involving the macula in...

Retinoblastoma management update (part 1): clinical features, diagnosis and genetics

1 January 2017 | | EYE - Oncology
The first of a two part series, this article will discuss the clinical features, diagnosis and genetic aspects of retinoblastoma. Manoj Parulekar is based at Birmingham Children’s Hospital, one of the two designated national retinoblastoma and paediatric ocular oncology treatment...

Patient and public participation shapes biomedical research and access priorities in eye health

1 December 2014 | | EYE - General
Patients, clinicians and clinician-scientists play a valuable role in shaping the future of vision research. Limited funding demands targeted research initiatives that ultimately will shape health policy and practice to secure progress in improving patient outcomes in eye health. This...

Isolated trochlear (fourth cranial) nerve palsy in an Asian population

1 August 2018 | | EYE - Neuro-ophthalmology
The authors report on 35 consecutive new cases of isolated fourth cranial nerve palsy seen over a period of six months in one neuro-ophthalmology clinic in Southeast Asia, with emphasis on their aetiology and management. We report on 35 patients...

Management of proliferative diabetic retinopathy

1 August 2014 | | EYE - Vitreo-Retinal
Diabetic retinopathy is a major cause of blindness in the working-age population. Due to the worsening global epidemic of diabetes, the incidence of morbidity caused by the disease is set to increase [1]. The prevalence of diabetes in the UK...

Unconscious bias (part 2)

5 February 2020 | | EYE - General
Does unconscious bias exist, and does training help to reduce discriminatory behaviour? Clare Inkster questions her role as a trainer. I read Gwyn Williams’ Learning Curve article on this topic a few months ago with interest, and as someone who...

Post-Brexit deal welcomed but leaves future relationship with EU far from settled

6 April 2021 | | EYE - General
Rod McNeil breaks down the impact of the Brexit deal on healthcare in the UK, including medicines regulation, research funding, sharing of information and the ability to work abroad. A disorderly no-deal exit from the European Union (EU) was averted...

Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service

4 August 2021 | | EYE - Paediatrics, EYE - Vitreo-Retinal, EYE - General
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...