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My Top Five: Promising gene therapies for ocular conditions
Gene therapy, a pivotal advancement in modern medicine, particularly shines in ophthalmology. By targeting defective genes with engineered vectors, this approach promises significant strides in treating inherited retinal diseases. This article reviews the top five gene therapies in late-stage trials,...My Top Five: Promising gene therapies for ocular conditions
Gene therapy, a pivotal advancement in modern medicine, particularly shines in ophthalmology. By targeting defective genes with engineered vectors, this approach promises significant strides in treating inherited retinal diseases. This article reviews the top five gene therapies in late-stage trials,...
Prognosis of ocular motor cranial nerve palsies caused by pituitary adenoma and meningioma
The authors present a retrospective cohort study with the aim of comparing recovery rate and time of ocular motor cranial nerve palsies (CNP) caused by pituitary adenoma or meningioma. Cases were identified from a single tertiary referral centre over a...
How does teprotumumab impact on ocular misalignment in thyroid eye disease?
A retrospective case review was conducted with the aim of exploring the effect of teprotumumab on objective diplopia. Adults diagnosed with thyroid eye disease, presenting with diplopia and receiving a standard six-month treatment with teprotumumab at a single centre were...Perioperative nursing considerations for ocular patients on GLP-1 and SGLT2 inhibitor medications
New antihyperglycaemic drugs are now increasingly used to treat individuals with and without diabetes mellitus to reduce their cardiovascular and renal morbidity and mortality [1]. These include glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucosecotransporter-2 (SGLT2) inhibitors. Glucagon-like peptide-1 receptor...Renewed momentum in ocular gene and cell therapy, broadening application to chronic disease
Gene and cell therapies offer the prospect of ground-breaking new avenues for the treatment of diseases, reflected in a renewed explosion of interest and investment in retinal gene therapy. Rod McNeil reports recent clinical trial readouts across a diverse range...Reichert Ocular Response Analyser® G3
Make a more confident glaucoma risk assessment with Corneal Hysteresis. ORA® G3 is the only tonometer that measures Corneal Hysteresis (CH), a superior predictor of glaucoma progression. CH is an indication of the biomechanical properties of the cornea, differing from...
Systemic rituximab immunotherapy in the management of primary ocular adnexal lymphoma single institutional experience
Ocular adnexal lymphomas constitute 2% of all non-Hodgkin’s disease and 5-15% of all extranodal lymphomas and are usually localised, low-grade and of B-cell origin. This opens them up to potential treatment with a systemic monoclonal antibody-based drug (rituximab) directed at...
Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders
Medical records of 15 paediatric patients (onset before age of 16) affected by refractory non-infectious uveitis (NIU) and treated by tocilizumab (TCZ) were reviewed. Data were extracted from the international AIDA Network for uveitis registry and Behcet’s disease registries. They...
Real-world experience of using ciclosporin-A 0.1% in the management of ocular surface inflammatory diseases
This is a retrospective study of patients with ocular surface inflammatory diseases (OSIDs) treated with IKERVIS in a single centre between 2016 to 2019 with at least six months follow-up. Clinical outcome was defined as successful (resolved or stable disease),...
Low dose steroids for ocular dry eye disease in graft vs. host disease
This double-masked randomised clinical trial compared the response of dry eye disease (DED) to treatment with topical steroids in patients with and without graft vs. host disease (GVHD). Forty-two patients in a single centre (n=21 with and n=21 without GVHD)...
