You searched for "gene therapy"
Therapeutic options for advanced cutaneous basal (BCC) and squamous cell carcinomas (SCC)
This article discusses the use of topical and systemic therapy in the management of advanced periocular tumours. It focuses on those that have gained United States Food and Drug Administration approval; namely imiquimod, vismodegib, sonidegib, pembrolizumab and cemiplimab. Imiquimod is...
Ophthalmic presentations and outcomes in Erdheim-Chester disease
This is a comprehensive article describing clinical manifestations and pathogenesis of Erdheim-Chester disease (ECD) followed by a literature review of the available treatments. The authors look to compare historical treatment (HT) with vemurafenib, a BRAF inhibitor. ECD is a non-Langerhans...
The effect of orbital decompression on upper eyelid retraction
This is a systematic review and meta-analysis on whether there is a change in upper lid retraction following orbital decompression. Traditional teaching states that the order of surgery for thyroid eye disease should be decompression firstly, followed by squint surgery...Glaucoma care provision using a multidisciplinary approach: a personal view
This article is going to explain the secret to running an efficient multidisciplinary glaucoma service which will comfortably meet the demands of an ever-growing elderly population, within the confines of budgetary and clinical constraints, wherever the setting. This may be...Development of eyecare services in Dominica: Past, present, and future
Dominica is a small island developing state in the Caribbean with a population of approximately 73,000 people [1] and has a long and proud history of developing eyecare services through international partnerships. This article will give you an outline of...Advances in cataract surgery
This article covers recent clinical findings in mydriasis and anaesthesia for cataract surgery, shared by Sathish Srinivasan and Keith Davey at a surgical meeting in Manchester. Towards dropless cataract surgery Day case cataract surgery is the standard of care in...
Chronic lymphocytic leukaemia (CLL) of the lacrimal sac
The authors present a case series of three patients with known CLL, two of which presented with mass and epiphora and one case with epiphora alone. All three patients had initially being diagnosed and were treated for chronic dacryocystitis. Histopathological...
Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells
There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...
Germline mutation risk in solitary unilateral retinoblastoma
This study aimed to determine the true risk for germline mutation in a child presenting with solitary unilateral RB and whether this risk differs by age at presentation. This was a retrospective review of 482 cases from 1972-2020. Age groups...
Retinoblastoma mortality associations with choroidal and optic nerve invasion
The authors present a retrospective cohort study. Data was extracted from the National Cancer Institute’s Surveillance Epidemiology and End Results (SEER) database, based in the US and founded in 1973. Cases of retinoblastoma were extracted using the inclusion criteria of...
