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OCT in proliferative diabetic retinopathy

This report set out to describe the anatomical relationships between retinal neovascular complexes (NVC), the posterior vitreous, and the vitreoretinal interface in patients with proliferative diabetic retinopathy using spectral domain OCT. The following was recorded for each NVC 1) posterior...

A possible biomarker for diabetic retinopathy

Diabetic retinopathy (DR) is the most common form of diabetic eye disease, characterised by exudates, microaneurysms and haemorrhage. Early diagnosis is crucial for preventing visual loss. The risk of developing diabetic retinopathy is known to increase with age as well...

Myopia-protective against diabetic retinopathy

This meta-analysis evaluates the current evidence of the relationship between myopia and diabetic retinopathy (DR) risk. A systematic search was performed up to April 2015. Three models were used to assess the association between myopia and risk of DR: axial...

Medical management and diabetic retinopathy progression

The ACCORD Eye Study was designed to evaluate the benefit of intensive glycaemic control (HbA1c <6.0% vs 7.0-7.9%), intensive systolic blood pressure control (<120mmHg vs. <140mmHg), and combined fenofibrate and simvastatin therapy in the development and progression of diabetic retinopathy....

Inflammation and microvascular changes in diabetic retinopathy

Studies have shown that neurodegeneration and inflammation in the retina start early in diabetic retinopathy (DR) and can be present before the latter is clinically evident. The aim of this retrospective review of 99 diabetic patients was to evaluate retinal...

Effect of heredity on risk of diabetic retinopathy

This study used survival analysis on 2199 patients who had reached vision-threatening diabetic retinopathy to investigate the contribution of heredity to diabetes together with other known risk factors for the development of either proliferative diabetic retinopathy (PDR) or diabetic macular...

Automated grading of diabetic retinopathy: is it possible?

Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes and a leading cause of blindness worldwide. However, much of this diabetic blindness can be delayed or even prevented with timely diagnosis and proper treatment. For this reason, regular screening...

Retinal ganglion cell loss in diabetes and diabetic retinopathy

The aim of this observational case control study was to evaluate the association of diabetes and diabetic retinopathy (DR) with retinal ganglion cell loss. Cases were Chinese patients with type 2 diabetes with and without DR, aged 40-80 years. Eligible...

Diabetic polyneuropathy and risk of developing diabetic retinopathy

Diabetic polyneuropathy (DPN), diabetic retinopathy (DR) and diabetic nephropathy are widely classified as microvascular complications of diabetes. DPN, which may cause complete sensation loss, is another common complication of DM. The DPN-related diminished sensation presents a significant risk factor for...

Hyper reflective foci (HRF) on OCT in diabetic retinopathy

This study investigated the presence of hyper reflective foci (HRF) in asymptomatic patients affected by type 1 or type 2 diabetes, separately, without clinically significant diabetic macular oedema and visual impairment. In total 71 eyes with non-proliferative diabetic retinopathy were...

Akimba mice, a model of human diabetic retinopathy

Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...