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New mouse model of diabetes mellitus

1 April 2014 | | Retina / Uvea / Vitreous | aldose reductase, cell signaling P-ERK1/2, P-SAPK/JNK, P-Akt, diabetic rats, diabetic retinopathy, green fluorescent proteins, growth factors VEGF, bFGF, TGF-β, retinal vascular changes, transgenic diabetic mouse models
Diabetic retinopathy (DR) is a serious complication of diabetes. It is driven by the loss of pericytes, cells which control vascular function, due to excess formation of sugar alcohols by the enzyme aldose reductase (AR). AR has been shown to...

Systemic and Ophthalmic Management of Diabetes Mellitus

1 April 2019 | | Retina / Uvea / Vitreous, Ophthalmology, Optometry
Chris Steele, the Head of Optometry in Sunderland Eye Infirmary, has a wealth of experience and knowledge in retinal pathology and has recently published what is now his second book on diabetes. This has been a major undertaking, taking three...
Ophthalmic Epidemiology cover picture

Association between diabetes mellitus and dry eye disease

1 April 2020 | | Retina / Uvea / Vitreous
Diabetes mellitus (DM) is currently one of the most prevalent chronic diseases in the United States. It is estimated that 12.3% of Americans suffer from DM. In this study the authors compare between dry eye and diabetes mellitus among a...
Ophthalmologica journal cover image

Correlation between aqueous flare and macular microvascular status in diabetes mellitus

7 April 2021 | | Retina / Uvea / Vitreous | Aqueous flare, Diabetic retinopathy, Inflammation, Laser flare-cell meter, Microvascular injury, Optic coherence tomography angiography
The authors report a cross-sectional study which was conducted to investigate the correlation between aqueous flare and macular microvascular status, assessed by optic coherence tomography angiography (OCTA) in diabetes mellitus. Fifty-two diabetic patients with non-proliferative retinopathy, 44 diabetic patients without...

Cataract incidence rates in patients from the UK suffering with diabetes mellitus

1 October 2018 | | Cataract and Refractive, Ophthalmology
The authors summarise the main findings from a recent study which investigated the incidence rates of cataract in patients with or without diabetes mellitus (DM). Background to the study Worldwide, the World Health Organization (WHO) estimates that 253 million people...

Sustainable prevention of blindness from diabetic retinopathy through prevention and control of diabetes mellitus – LINK partnership experience in Dominica

1 October 2018 | | Ophthalmology, Retina / Uvea / Vitreous
The Caribbean Diabetic Retinopathy Project (DR Caribbean) is a five-year project that aims to reduce blindness due to diabetic retinopathy (DR) across four Commonwealth countries: Belize, Dominica, Jamaica and St Lucia. The VISION 2020 LINKS Programme at the London School...