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Long-term effect of gene therapy on Leber’s congenital amaurosis

After reporting the first successful gene therapy results for RPE65 deficiency in three patients in a brief report in 2008, the same team from London now report the results of 12 patients followed up for three years after transfection. As...

Outcomes of early versus late surgery for infantile esotropia

The authors aimed to provide a better understanding of the clinical spectrum of infantile esotropia by comparing motor and sensory results in the long-term follow-up of patients who underwent surgery. This was a retrospective review over a 17-year period. There...

AI & Oculomics: a new section for Eye News

Inaugurating this new regular section on the exciting landscape of AI and oculomics, we provide an overview which delves into the historical context and the etymology of this field, reviews the current state of play and contemplates possibilities and hopes...

Pseudophakic Monovision: A Clinical Guide

The contents of this small volume should provide useful tips for all ophthalmic practitioners involved with managing patients undergoing cataract surgery. For those ophthalmic clinicians and supporting staff not familiar with the potential options for achieving a spectacle independent refractive...

Friends of Moorfields shortlisted for the Charity Awards 2025

We are delighted to announce that we have made the shortlist for this year’s Charity Awards, the longest-running awards scheme in the charity sector. Friends of Moorfields has been shortlisted in the Healthcare and Medical Research category for our handholding...

15 prism test for anisometropic amblyopia

The authors aimed to investigate the accuracy of the 15^ base in prism test (BIPT) in detecting amblyopia in anisometropic patients. This was a retrospective study in which the 15^BI was placed before the right eye followed by the left...

Ocular ischaemic syndrome in a rat model

Ocular Ischaemic syndrome is a devastating eye disease caused by severe carotid stenosis. This study’s purpose was to develop a reliable rat model for this syndrome by subjecting rats to common carotid artery occlusion and sham surgery. Rats were assigned...

Large collar diameter Jones tubes

This is the first report of the success rates of frosted Jones tubes with larger diameter, 4.5 or 5mm collars. This is a retrospective review of 29 eyes of 25 patients who underwent insertion of a large diameter collar frosted...

Aberrant regeneration rates following traumatic oculomotor palsy

Traumatic oculomotor nerve palsies can result in aberrant regeneration / synkinesis which impairs normal facial function. In this paper, the authors retrospectively reviewed the records of 16 patients with traumatic oculomotor nerve palsies who were treated with or without steroids....

Narrative review of idiopathic intracranial hypertension in children / adolescents

Idiopathic intracranial hypertension (IIH) affects both children and adults. Whilst the majority of IIH is mainly seen amongst adults, it also affects children. There are currently no clinical trials in IIH for those who are adolescents or children. The aims...

What to expect when meeting a statistician

There are a growing number of statisticians working closely with ophthalmologists. They have different training but they are driven by the same goal: to perform high quality evidence based clinical research [1,2]. In a perfect world we would simply conduct...

Effective treatment for rare sight-threatening infection

A drug candidate, based on pioneering UCL and Moorfields Eye Hospital research and currently under development by SIFI S.p.A., has been found to be highly effective in treating a rare sight-threatening eye infection in a new international clinical trial.