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A case series of acquired esotropia in cerebellar disease
Acquired esotropia in cerebellar disease is well described but under-recognised. The pathogenesis of cerebellar esotropia is controversial. It is suggested it may be a result of disruption to central vestibular pathways. This article reports a case series of seven adults...House of cards
When I was a junior doctor in the late 1990s writing my first scientific papers, once each article was finished, I had to fill out an application form, print out multiple copies and then walk to the post office at...
Comparison of ganglion cell thinning in glaucoma vs. macular hole repair
This prospective study compared the changes in the photopic negative response of the focal macular electroretinogram (fmERG) caused by retinal ganglion cell complex (GCC) thinning at the macula between patients with open angle glaucoma (OAG) and 12 months after successful...Understanding spaceflight-associated neuro-ocular syndrome (SANS): what do we know?
Introduction Formerly known as visual impairment and intracranial pressure syndrome (VIIP), space-related neuro-ocular syndrome (SANS) is defined by a collection of ophthalmic and neurological findings in astronauts after long-term spaceflight [1]. Changes in the eyeball, such as hyperopic shift, during...The fragile p-value
Abdus Samad Ansari explores the limitation of the p-value and the application of the fragility index in clinical trials. Clinical trials and tribulations? The restoration of vision or more purely the gift of sight is an aspect of care that...
Changes in the prevalence of myopia in middle-aged caucasian Australians compared to UK biobank
This article compares rates of myopia and high myopia in large cohorts of caucasian Australians from the Busselton Healthy Ageing Study, the urban Gen1 of the Raine Study, the Blue Mountains Eye study and Melbourne Visual Impairment Project. The former...
Function vision outcomes in pseudophakic children
This study evaluated the functional vision of 196 pseudophakic children and their carers treated at a tertiary centre in Southwest Nigeria and identified association factors. Mean age was 9.8 ±3.4 years (range 2–16) with 68.9% male and 31.1% female. Median...
Conjunctival inflammation in glaucoma patients
Numerous studies have demonstrated that topical medications and preservatives used for the management of glaucoma can induce significant histopathologic and inflammatory changes in the ocular surface. This study describes an increased expression of major histocompatibility complex class II antigen HLA-DR,...The GMC joins the mobile revolution
If you are an ophthalmologist practising in the UK the increasing need to log your educational activities for your Annual Review of Competence Progression (ARCP) or appraisal can’t possibly have escaped you. The existing tools in this area for ophthalmologists...
A phase 3 randomised trial of nicotinamide for skin cancer chemoprevention
To B3, or not to B3? That was the question asked in this controlled trial in which the authors were able to show that oral nicotinamide (vitamin B3) is able to reduce further skin cancer development in high risk patients....Birdshot retinochoroiditis
Birdshot retinochoroiditis (BRC) is a chronic, sight-threatening uveitis, most commonly affecting caucasian individuals in their fourth to sixth decades [1]. The disease is associated with HLA-29 and is characterised by progressive inflammation at the level of retina and choroid, with...
