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Brolucizumab in age-related macular degeneration, HAWK Study
The aim of the study was to collect additional data on efficacy and safety of brolucizumab 6mg intended for commercialization in age-related macular degeneration (AMD) (with an increase in pH and decrease in polysorbate concentration). The HAWK Study was a...
Bromfenac versus betamethasone in diabetic macular oedema
This is a randomised, prospective, single-centre trial in patients diagnosed with diabetic macular oedema (DMO) with central subfield thickness (CST) of 250-500µm, who refused anti-VEGF treatment. Nineteen eyes of 19 patients were randomised to bromfenac (BF) or betamethasone (BM) drops,...
Visual snow syndrome: a review
Visual snow syndrome (VSS) is a neurological condition characterised by visual phenomena described as dots moving across the visual field. Other visual symptoms can take the form of palinopsia, entopic phenomena, photophobia and nyctalopia. Tinnitus and migraine can be commonly...
Natural history of optic nerve head drusen in a paediatric population
A retrospective case notes review is presented focusing on children diagnosed with optic nerve head drusen over an eight-year period. Inclusion criteria included cases coded for optic nerve head drusen and / or pseudopapilledema. The aim of the study was...
Features of branchio-oculo-facial syndrome
Branchio-oculo-facial (BOF) syndrome is an autosomal dominant inherited syndrome that typically presents with branchial cleft sinus defects, ocular anomalies and dysmorphic facial appearance. The authors present a new case alongside the results of a literature review describing the common genetic...
A review of neuro and retinal imaging findings in Alzheimer’s disease
The authors present a systematic review with the aim of assessing the relationship between retinal and cerebral changes in Alzheimer’s disease (AD), mild cognitive impairment and pre-clinical AD. A total of 23 articles met the inclusion criteria of the review,...
Combined in-office and home-based eccentric viewing training for central vision loss
This retrospective study aimed to investigate the effectiveness of an eccentric viewing training (EVT) programme delivered in a real-world setting (home exercises) by combining a traditional EVT technique with biofeedback training using microperimetry. The authors investigated potential relationships between visual...
Diagnosis and management of paediatric keratoconus
This article reviews the current literature on paediatric keratoconus diagnosis and management. Paediatric cases pose challenges as they may not vocalise unilateral changes, difficulty in obtaining reliable imaging, faster rates of progression, difficultly with contact lenses and presumed worse outcomes...
The compendium to clinical evidence in DMO treatment
This review article summarises the current evidence base in the treatment options for diabetic macular oedema (DMO). The authors have included many real-world data studies that provided valuable insights into the optimal management of DMO. The authors argue that these...
Macular pigment in relatives of AMD patients
Blue light causes photo-oxidative retinal injury and macular pigment (MP), with lutein, zeaxanthin and mesozeaxanthin as the main components, as a filter that protects the macula from this damage. Previous studies indicated that low levels of macular pigment optical density...
Clinical predictors of proliferative sickle cell retinopathy
Sickle Cell Disease (SCD) is an inherited disorder resulting in production of Haemoglobin S (HbS), which aggregates in conditions of hypoxia, acidosis or hyperosmolarity. This leads to vascular stasis, thrombosis and ischaemia. The authors present a cross-sectional study (45 consecutive...
