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A rare case of endogenous panophthalmitis: Nidus from an E. coli urinary tract infection
Endogenous bacterial endophthalmitis (EBE) is a form of severe inflammation caused by haematogenous spread of a virulent bacterium from a nidus elsewhere in the body to intraocular tissues. It is a rare occurrence and only constitutes around 2–8% of all...Broadening of treatment options for potentially blinding retinal conditions
Rod McNeil provides an update on a promising bispecific antibody recently approved for treatment of neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO) and considers emerging developments in biosimilars to established anti-vascular endothelial growth factor (anti-VEGF) therapies, including...Demyelinating optic neuropathy
Introduction Optic neuritis (ON) is an inflammatory process affecting the optic nerve. After glaucoma, it is the most common optic neuropathy affecting patients under the age of 50. The usual presentation of typical ON is unilateral subacute loss of vision...Keep calm and cut the carbon – improving sustainability in ophthalmology
As I dump my tenth pair of gloves into a non-recyclable clinical waste bin; dispose of another handful of plastic minims; or print another wad of single-sided discharge paperwork after a cataract surgery, the inconvenient truth of how these seemingly...Exploiting nature’s randomised trials of eye disease
Confounding and reverse causation in observational ophthalmic epidemiology Traditional observational studies are inherently limited in establishing a causal effect of an exposure on an outcome of interest. One fundamental limitation is confounding, whereby causation is incorrectly attributed to a third...Scholarships, awards and prizes
Perhaps one of the less well-known benefits of being a member of the Royal College of Ophthalmologists (RCOphth) is access to the range of scholarships, awards and prizes that we offer. Many of you will be aware of the annual...Paediatric choroidal neovascular membrane secondary to optic disc drusen
Choroidal neovascular membrane (CNVM) is a rare cause of visual impairment in paediatric populations and predominantly affects individuals aged over 50. CNVM is defined as the pathologic growth of new abnormal blood vessels which extend from the choroid and break...The paediatric cataract: an overview of the embryology and pathophysiology
In the first of the two articles (see Part 2 here) on paediatric cataracts, Samuel Aryee reviews the aetiology of this condition. Cataracts arise from opacification of the natural transparent lens, which can cause partial or total blindness. Although the...Investigating the link between corneal clarity and statin use
Transparency is a vital attribute of the cornea, necessary in preserving healthy vision. Maintaining this requires the collective input of the various layers of the cornea. Mostly, the layers implicated in this are the corneal stroma and endothelium [1]. Our...
Corneal Collagen Cross-Linking
As the title suggests, this publication provides a single volume that collates much of the current knowledge and application for corneal collage cross-linking (CXL). There are 23 chapters, subdivided into seven sections, including five pages of indices. The chapters are...
What about the children? Cornea cross-linking for children with keratoconus
Keratoconus can behave more aggressively in paediatric than in adult patients. Collagen cross-linking has been shown to slow the progression of keratoconus in adults. This systematic review determined the effectiveness of corneal collagen cross-linking (CXL) in children. For this study,...
