You searched for "retina"
Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells
1 October 2016
| Bheemanagouda Patil
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EYE - Vitreo-Retinal
There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...
Myopic choroidal neovascularisation
1 August 2015
| Jonathan Chan
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EYE - Vitreo-Retinal
This is a review article summarising the latest myopic CNV (choroidal neovascularisation) literature in the clinical experience and management outcomes for recommendation algorithm. The aetiology of the myopic CNV was discussed by the authors under the heading of the heredo-degenerative...
Are retinal vein occlusions seasonal? And if so why might that be?
1 June 2015
| Jonathan CP Roos
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EYE - Vitreo-Retinal
Some studies have reported a strong seasonal pattern to central retinal vein occlusion (CRVO) occurrence with a peak in January, but other studies have failed to replicate this finding. The authors sought to determine data for Stockholm’s seasonal variation in...
Intravitreal dexamethasone implant for diabetic macular oedema
The authors report on the three-year outcomes of the Ozurdex Dexamethasone (DEX) intravitreal implant multi-centre trial for the treatment of diabetic macular oedema (DME). Patients with DME (best-corrected vision of 20/50 to 20/200 and central retinal thickness of ≥300µm) were...Ranibizumab versus laser in diabetic macular oedema (LUCIDATE study)
1 October 2014
| Efrosini Papagiannuli
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EYE - Vitreo-Retinal
The aim of this study was to compare the functional and structural effects of Ranibizumab versus macular laser treatment in patients with diabetic macular oedema. It was a single centre, prospective, randomised, single masked clinical trial spanning a 48 week...
Effect of change in retinal nerve fibre layer thickness on quality of life in patients with glaucoma
1 October 2015
| Lona Jawaheer
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EYE - Glaucoma
The authors investigated the relationship between structural changes in glaucoma (retinal nerve fibre layer (RNFL) thickness) and quality of life (as measured by the NEI VFQ-25 questionnaire) over a period of time. Two hundred and sixty eyes of 130 patients...
Long-term effect of gene therapy on Leber’s congenital amaurosis
1 October 2015
| Jonathan CP Roos
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EYE - Vitreo-Retinal
After reporting the first successful gene therapy results for RPE65 deficiency in three patients in a brief report in 2008, the same team from London now report the results of 12 patients followed up for three years after transfection. As...
Morning glory syndrome associated with PHPV
1 February 2014
| Jonathan Chan
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EYE - Glaucoma
This is a retrospective review of the medical records of 85 eyes / 74 patients diagnosed as morning glory syndrome (MGS) in the clinic between November 2009 and November 2012. Twenty two eyes of 19 patients diagnosed as having MGS...
Association between serum triglycerides and pan retinal photocoagulation in type 1 diabetes
1 December 2013
| Khadijah Basheer
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EYE - Glaucoma
This retrospective cohort study aimed to examine whether dyslipidaemia is a risk factor for progressing to proliferative diabetic retinopathy (PDR) and consequently requiring pan retinal photocoagulation (PRP) treatment in type 1 diabetics. In previous studies including the ETDRS study an...
Can retinal layer thickness predict the progression of disability in MS?
1 December 2021
| Lauren R Hepworth
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EYE - Neuro-ophthalmology
This is an observational retrospective cohort study presenting the data of 188 patient diagnoses with multiple sclerosis at two specialist centres. All included patients were adults below the age of 70 years, stable on their disease modifying treatment for at...
Progression of macular atrophy on long-term anti-VEGF therapy for AMD
3 October 2022
| Sofia Rokerya
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EYE - Vitreo-Retinal
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Anti-VEGF therapy, Long term, Macular atrophy, neovascular age-related macular degeneration
This retrospective study evaluated the progression of macular atrophy in 53 eyes of 53 patients receiving AntiVEGF Therapy for age-related macular degeneration (nAMD), for at least six years. None of the patients had any macular atrophy (MA) at presentation. MA...
PRPF31-related retinitis pigmentosa and asymptomatic carriers
1 March 2024
| Ian Reekie
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EYE - Vitreo-Retinal
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FST, PRPF31, RP11, Retinitis pigmentosa, asymptomatic carriers, non-penetrance
The authors present a study of 21 patients with variants in the PRPF31 gene classified as pathogenic or likely pathogenic. These variants are caused by autosomal dominant retinitis pigmentosa (RP-11). Between January 2020 and November 2021 patients underwent tests of...