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Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
PD-1 and PD-L1 in exenteration specimens
This is an immunohistochemical study looking at variation in the expression of the programmed death-1 receptor (PD-1) and the programmed cell death ligand-1 (PD-L1), comparing cutaneous malignancies which invaded the orbit with uncomplicated nodular basal cell carcinomas. The authors retrospectively...Hospital wins funding to investigate sickle cell sight loss.
The hospital trust is the first in the UK to lead on a research project to understand the impact of sickle cell disease on eyesight.Proning and the pandemic - ocular complications seen in critical care
Priyanka Sanghi and her co-authors explore the ocular complications seen in critical care units throughout the country as we treat patients through this challenging time. The SARS-Cov-2 (COVID-19) pandemic has placed the NHS and critical care services under immense strain,...Ophthalmology in Bangladesh
Imaging Specialist Hayley Coates steps outside her comfort zone to experience ophthalmology in a resource-poor setting. As one of the most densely populated countries in the world, Bangladesh also has one of the highest rates of preventable blindness, worldwide. It...You want to do paediatric ophthalmology? Seriously?
Completion of Core Training is approaching fast and you begin to wonder three things. One, where do you want to live? Two, is anyone going to be retiring there soon? Three, what subspecialty do you want to do? In an...If looks could kill – kohl and the eye
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are based on facts and which are ‘fake news’. Headline: If looks could kill – kohl and the eye Human fascination with beautification can be traced...Update on emerging therapies for age-related macular degeneration
The 23rd European Society of Retina Specialists (EURETINA) Congress, held in Amsterdam, the Netherlands, provided a timely update on anti-complement therapy for geographic atrophy and emerging investigational therapies for neovascular age-related macular degeneration. Anti-complement therapy for geographic atrophy Geographic atrophy...The results of the last survey Oct22
I thank everyone for their time in responding to this edition’s survey questions. The first question relates to an issue I have previously discussed around consent for second eye cataract surgery. I touch on this point again for two reasons....
Using perimetry to support lesion location in the retrochiasmal visual pathway
The authors present a retrospective case review of patients with homonymous hemianopia from a 30-year period. Inclusion criteria included completion of perimetry within two years of diagnosis and a MRI brain. Data extracted from the records included demographics, diagnosis details...
