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Conservative surgical management of optic disc pit maculopathy

Four cases are presented in this case report that illustrates the option of conservative surgical management for optic disc pit complicated by maculopathy (ODP-M). Four men aged 24-67-years-old with no spontaneous resolution of ODP-M for a minimum of three months,...

Addressing childhood blindness in sub-Saharan Africa

In this article, the authors explore paediatric ophthalmology subspecialist fellowship training in African nations south of the Sahara. Until recently, most African ophthalmologists who wished to pursue a subspecialty ophthalmology training fellowship had to go abroad. There is a huge...

The role of inflammation in the pathophysiology of DMO

Diabetic macular oedema (DMO) is a major cause of visual loss in diabetes, with a complex multifactorial pathogenesis. In the UK alone it is estimated that there are nearly 2.5 million diabetic patients aged over 12 years. Approximately 65,000 of...

Differential inhibition of EAU by CTLA4 and IL-6

Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...

Air or SF6 in DMEK

This retrospective study compared descemet’s membrane endothelial keratoplasty (DMEK) outcomes in 136 consecutive eyes of 68 patients. All patients underwent DMEK for Fuch’s endothelial dystrophy, where consecutive eyes received 100% air bubble during first eye surgery and 20% sulphur hexafluoride...

Efficacy of combined vitrectomy with intravitreal corticosteroid injection for ERM

In this study the authors evaluated the efficacy of vitrectomy combined with corticosteroid injection for idiopathic epiretinal membrane (ERM). A systematic literature review was conducted by searching three electronic databases, PubMed, Embase and Medline, up to 2020 for relevant studies....

Orbital cellulitis in Scotland: current incidents, aetiology, management and outcomes

This is a one year prospective study using the Scottish ophthalmic surveillance unit reporting system amongst Scottish ophthalmologists. Only patients residing within Scotland with a new diagnosis of orbital cellulitis between November 2011 and October 2012 were including in this...

Stereotactic radiotherapy for polypoidal choroidal vasculopathy

Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular AMD. It is a disease of choroidal vasculature characterised by abnormal branching vascular network with aneurysmal dilatations (polyps). Features of PCV include pigment epithelial detachments (PED), subretinal fluid (SRF) accumulation and...

My Top Five: Visionary inventions in ophthalmology

When we see how technologically forward and advanced modern-day medicine is, we forget that it is also an age-old, ancient profession with a rich, intriguing history that we remain unaware of. Ophthalmology in particular has always been at the forefront...

AI detects eye changes that lead to sight loss in young people

Use of Artificial Intelligence (AI) can accurately predict when young people with the sight- threatening eye condition kerataconus need treatment to stabilise the cornea and prevent loss of vision. Developed by researchers at Moorfields Eye Hospital and UCL Institute of...

A window to 2024 and beyond?

The connection between the eye and systemic diseases has been acknowledged for millenia. Historical records suggest that ancient civilisations had some understanding of the eye’s significance beyond its primary function in vision. For instance, in ancient Egypt, the ‘Eye of...

Cell injection therapy for endothelial failure

This is a prospective observational study involving 11 eyes of 11 patients with pseudophakic endothelial failure who underwent human corneal endothelial cell culture (hCEC) injection therapy for endothelial failure. This study aimed to evaluate the long-term five-year postoperative data for...