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Intravenous paracetamol in orbital surgery
This is a large prospective study of the effect of intravenous acetaminophen (paracetamol) in orbital surgery. The study included three groups of 50 patients. One group had no i.v. paracetamol, the second 1g of i.v. paracetamol within 30 minutes of...
Anterior segment OCT predicts gonioscopic angle closure
This is a prospective observational study of 342 subjects over four years. Sixty-five were controls who had open angles both on gonioscopy and AS-OCT, while 277 had open angles only on gonioscopy but iridotrabecular contact (ITC) on AS-OCT (one to...
PD-1 and retinal ganglion cell death
Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...
Statins inhibit TGFβ2 mediated fibrotic response in astrocytes
Glaucoma is a common condition where increased ocular pressure can lead to death of retinal ganglion cells due to impaired drainage of fluid from the eye. One mechanism involved in glaucoma is remodelling of the extracellular matrix at the lamina...
Association between colour vision impairment and amyotrophic lateral sclerosis (ALS)
The purpose of this study is to test the hypothesis that colour vision impairment is associated with amyotrophic lateral sclerosis (ALS). Abnormalities of the inner and intermediate retinal structures in patients with ALS have been described using optical coherence tomography...
Treatment for post stroke visual impairment – clinical practice versus literature evidence
The aim of this paper is to compare the treatments reported in a large scale stroke study (Vision in stroke (VIS) Study) against the treatments identified in a full systematic literature review. The purpose was to identify which treatment /...
Same day air bubble removal after DSEK/DSAEK
A complete air removal on same day as descemet’s stripping endothelial keratoplasty (DSEK/DSAEK) leads to prompt restoration of the anterior chamber and thus has been hypothesised to assist with the recovery of endothelial function and promote graft adhesion. The results...
Intravitreal aflibercept for diabetic macular oedema
The VISTA and VIVID randomised phase 3 trial were designed to compare the efficacy and safety of intravitreal aflibercept injections versus laser photocoagulation for diabetic macular oedema (DMO). A total of 872 patients with centrally involving DMO were recruited, and...
Toric intraocular lens rotation related to the capsulorrhexis
The risk factors for postoperative rotation in the early post-operative period; a longer axial length, younger patients, and with the rule astigmatism as described by Miyake T et al. (JCRS 2014) in a case series of six eyes. This letter...
Literature review of isolated ocular motor nerve palsies
Patients aged over 50 presenting with isolated nerve palsies of the third (pupil sparring), fourth or sixth nerves, are often described as having microvascular extraocular palsies. This review looks critically at the evidence surrounding these microvascular non-arteritic extraocular palsies and...
Choroidal thickness in strabismus and amblyopia
The authors examined the effect of exotropia, esotropia, anisometropic amblyopia and hypermetropia on choroidal thickness in a prospective cross section study. The study included 100 patients and 20 controls with a mean age of 8.5±2.9 years; 61 female and 59...
