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Developments in retinal pigmentation measurement and the hopes of an equitable future
Our AI & Oculomics co-editor, Nima Ghadiri, sat down with Abraham Olvera-Barrios from Moorfields and Anand Rajesh from the University of Washington to discuss their recent international study into retinal pigmentation and its wider clinical, technological and academic applications. Can...
The inflammatory side-effect of Brimonidine
Brimonidine is a well established selective alpha-2 adreno-receptor agonist, used to lower intraocular pressure. This case series reports on 19 eyes affected by brimonidine induced uveitis. Mean age of the patients was 74 years and mean duration of brimonidine use...
ARN in North Africa
Acute retinal necrosis (ARN) is a rare cause of uveitis. This paper aims to outline the clinical features of 12 patients with ARN in a referral centre in Tunisia, North Africa. A retrospective review of case notes was carried out....Therapy for limbal stem cell deficiency: cell fate after limbal stem cell transplants
“The beauty of scientific research lies in that the search for answers often yields yet more questions.” A large body of evidence points to the corneoscleral limbal location as the repository of putative epithelial stem cells [1]. Thoft proposed the...Non-organic visual loss
Patients can present to eye departments with various signs and symptoms (mostly symptoms) with no obvious organic cause. These patients can be labelled with any of a wide range of diagnoses such as functional visual loss, functional overlay, psychosomatic reaction...Myopia management
With the growing prevalence of myopia at epidemic levels in some countries and increasing number of research publications on myopia control, there is a lot of controversy regarding the management of myopia. As none of them are at present available...
Resveratrol protects against steroid induced intraocular pressure
Topical and systemic steroid delivery is a very effective treatment for many ocular conditions but is compromised by raised intraocular pressure which in turn leads to death of retinal ganglion cells and irreversible blindness. This is an important consideration with...
Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
Statins inhibit TGFβ2 mediated fibrotic response in astrocytes
Glaucoma is a common condition where increased ocular pressure can lead to death of retinal ganglion cells due to impaired drainage of fluid from the eye. One mechanism involved in glaucoma is remodelling of the extracellular matrix at the lamina...
Somatostatin protects retinal pericytes
Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood sugar levels damaging the retinal microvasculature. Mechanisms, such as oxidative stress and deposition of advanced glycation end products, leads to glial cell activation and neuronal apoptosis. Pericytes, contractile...
Cataract surgery and circadian photoentrainment
The study authors sought to investigate the possible effects of circadian photoentrainment following cataract. This was a randomised clinical trial, where 76 eyes of 76 patients (with bilateral cataract) were randomised to blue-blocking or neutral intraocular lenses (IOLs). Outcome measures...
