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Comparison of ketorolac 0.4% and nepafenac 0.1% for the prevention of CMO after phacoemulsification
This is a prospective randomised clinical trial study including patients older than 40 years with age related cataract and normal ophthalmic examination. The patients are randomised into three different groups and the objective of the study is to compare the...
Intensive diabetes therapy and ocular surgery in type 1 diabetes
The Diabetes Control and Complications Trial (DCCT) ran between 1983 and 1993 and showed that intensive glycaemic control was beneficial in reducing diabetic retinopathy in type 1 patients. There was a 76% reduction in onset of retinopathy and a 52%...
Long-term effect of gene therapy on Leber’s congenital amaurosis
After reporting the first successful gene therapy results for RPE65 deficiency in three patients in a brief report in 2008, the same team from London now report the results of 12 patients followed up for three years after transfection. As...
PI drops and respiratory change during surgery
Five percent povidone-iodine (PI) topical application to the eye has been observed to cause apnoea under general anaesthetic (GAS). The authors designed a randomised single-blinded controlled trial to evaluate changes in respiration caused by PI eye drops. They recruited 100...
Can coenzyme Q10 have a protective role in ethambutol-induced retinal ganglion cell toxicity
Tuberculosis (TB) is one of the most prevalent infectious diseases, especially in developing or low- income countries. Ethambutol is a widely used drug to treat TB. Ethambutol can cause visual disturbance including ethambutol toxic optic neuropathy (ETON). ETON is one...
Randomised controlled trial of CAM training vs occlusion for amblyopia therapy
The main aim of this study was to compare the effect of Cambridge vision stimulator (CAM) therapy with passive occlusion in the management of unilateral amblyopia. This was an randomised control trial (RCT) with two groups; group 1 with CAM...
Dexmedetomidine vs remifentanil for reduction of postoperative agitation
Postoperative agitation is a common anaesthetic complication in children with a significant impact to care and outcomes. The authors studied preschool children to compare the effect of intravenous administration of dexmedetomidine and remifentanil on postoperative agitation following strabismus surgery under...Effective treatment for rare sight-threatening infection
A drug candidate, based on pioneering UCL and Moorfields Eye Hospital research and currently under development by SIFI S.p.A., has been found to be highly effective in treating a rare sight-threatening eye infection in a new international clinical trial.Pioneering eye device restores reading vision to blind eyes
A pivotal European clinical trial of a new electronic eye implant has seen remarkable results. The study, published in the New England Journal of Medicine, showed 84% of participants were able to read letters, numbers and words using prosthetic vision...
Pseudostrabismus leading to strabismus
The authors aimed to evaluate the incidence of strabismus in children initially diagnosed with pseudostrabismus and identify risk factors for development of strabismus. This was a retrospective review of 65 patients with a diagnosis of pseudostrabismus; two exo and 63...
N-T asymmetry in tracking eye movements
The current study aimed to quantify and compare the visual tracking responses of two sensory induced strabismic juvenile monkeys during monocular smooth pursuit, ocular following response and optokinetic nystagmus (OKN). Monkey 1 had esotropia and monkey 2 had exotropia. Both...
