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Resolution of mid-peripheral schisis in x-linked retinoschisis with the use of dorzolamide

X-linked retinoschisis (XLRS) is an early onset hereditary retinal dystrophy. It is caused by mutations of the RS1 gene. Common manifestations of XLRS are schitic lesions at the macula, as well as infero-temporal schisis. Carbonic anhydrase inhibitors have previously been...

MicroRNA inhibits corneal neovascularisation

MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...

CSD-OCT detection of minimally visible retinoblastoma

This paper reports minimally visible tumour recurrence that was detectable on spectral domain OCT (SD-OCT) in a two-month-old infant who had a diagnosis of bilateral familial retinoblastoma. The infant was treated with IVC for six cycles with vincristine, etoposide and...

Identification and diagnosis of thalamic haemorrhage

This paper presents a case of thalamic haemorrhage and discusses clinical findings, providing valuable insight into signs clinicians need to look for. The case presented is of a 76-year-old female who developed left hemiplegia and hemi anaesthesia. Ocular motility testing...

Vision screening opinion

The aim of this paper is to describe experts’ perceptions of best practice guidelines and competency frameworks for visual screening in children. A focus group of approximately 75 minutes duration consisted of five orthoptists and two paediatric ophthalmologists with more...

Topical doxycycline for corneal neovascularisation

Six eyes with corneal vascularisation were treated with 1% topical doxycycline, four times a day for three weeks. The patients were reviewed at various intervals over a period of one year. The eyes selected had neovascularisation secondary to a variety...

Using a pupillometer to confirm presence of RAPD in post stroke homonymous hemianopia

It has been reported that relative afferent pupillary defects (RAPDs) may be present in patients with occipital lobe lesions. However, a small contralateral RAPD due to a difference in the crossed and uncrossed fibres can be difficult to detect using...

Fibrosis treated with amniotic membrane

In this paper, the authors describe the surgical management of complex strabismus using amniotic membrane grafts in six patients with complex, repeat previous strabismus surgery and two patients with periocular surgery. Frozen amniotic membrane allograft was used. The study had...

Fusional vergence measurement

This paper reports a systematic review to address two objectives: 1, to compare the normative values of tests measuring fusional vergence; 2, to investigate sources of heterogeneity of prism accuracy. The review was conducted according to PRISMA guidelines with a...

CAT-QoL questionnaire

The purpose of this study was to use Rasch analysis to inform the refinement of the CAT-QoL amblyopia treatment questionnaire. Of the 342 subjects that were recruited across nine centres, 315 had sufficient clinical data for analysis with RUMM software....

App detection of leukocoria

This paper outlines ARCELE – Computer Assisted Detection of Leukocoria. This is an iPhone app developed to increase early detection of retinoblastoma by detecting leukocoria. The aim of this study was to determine the use of CRADLE as a screening...

Orbital cellulitis outcomes for children

This paper discusses the clinical profile and multidisciplinary team (MDT) management outcomes in children treated for paediatric orbital cellulitis. This was a prospective study of 40 children with a mean age of 7.5 years (4-12). Unilateral orbital cellulitis cases had...