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γδ T cell depletion does not affect fungal keratitis

1 August 2015 | | EYE - Cornea, EYE - General | CFW, Cytokines, FK, Fungal keratitis, IL-17, Neutrophils, calcofluor WHITE, fungal keratitis, γδ T cells
Fungal keratitis (FK) is a blinding condition prevalent in agricultural areas of countries such as India and China. The fungus enters the cornea and induces an inflammatory response which leads to tissue damage. Neutrophils are the earliest infiltrating immune cells...

Corneal stroma modelling under hypoxic conditions

1 August 2018 | | EYE - Cornea, EYE - General | Confocal fluorescence microscopy, Cornea, Corneal organ culture, Extracellular matrix, Stroma
The cornea is exposed to hypoxia under several conditions including sleep, inflammation and wound healing. Being an avascular tissue to maintain transparency, how the cornea homeostatic controls oxygen tension is important. To address this process two models were utilised; a...

Erythropoietin in healing corneal epithelial defects in rabbits

1 December 2013 | | EYE - Cornea, EYE - General
Corneal epithelial defects heal slowly in patients with diabetes, limbal stem cell deficiency and severe chemical burns. Erythropoietin is a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors as well as nonhematopoietic cells. In...
British Journal of Ophthalmology cover image.

Factors influencing the outcome of GT and TBT in PCG

1 February 2022 | | EYE - Glaucoma | goniotomy, trabeculotomy, angle surgery, prognostic factors, paediatric glaucoma
This is a retrospective study between 2013 to 2016 of 452 eyes of patients </=12 years with primary congenital glaucoma (PCG), who underwent either goniotomy (GT) (median age: six months, 120 eyes) or trabeculotomy (TBT) (median age: 5.2 months, 332...

IOL power calculation accuracy in childhood cataract surgery

5 April 2022 | | EYE - Paediatrics, EYE - Strabismus
Refractive outcomes in eyes after vitrectomy vary as the timing of cataract surgery may influence the outcome when done as staged surgery after vitreoretinal (VR) surgery or at the same time as VR surgery. The authors aimed to determine the...

Unravelling ocular motility

1 April 2016 | | EYE - Neuro-ophthalmology
Ocular motility can often be a slightly abstract concept during the earlier years of ophthalmology training. A large variance on what embodies normality; mythical concepts like fusion and binocular vision, examination techniques that can be fiddly, and complex neuroanatomy all...

Diabetes and diabetic retinopathy: Changes in understanding of the disease over the last 25 years and how the UK is helping low-income countries tackle the challenges

1 June 2018 | | EYE - Vitreo-Retinal, EYE - General
Diabetes – a historical perspective Diabetes mellitus (DM) is a chronic disease caused by inherited and / or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. Such a deficiency results in...

Corneal transplantation in the United Kingdom: are we blind to the challenges that still exist after the Organ Donation Bill?

28 November 2022 | | EYE - Cornea, EYE - General
Corneal transplantation (CT) is a significant treatment option for a huge number of patients in the United Kingdom (UK) [1]. For an individual, CT results in a substantial improvement in quality of life. Penetrating keratoplasty with full thickness grafting has...

Working smarter not harder: How to transform eyecare delivery in the United Kingdom (part 1)

1 December 2021 | | EYE - General
Are we doing enough to meet the current demands on ophthalmic services? In part one of a two-part series (see Part 2 here), Rosalind Harrison takes a look at how efficiency has been improved in eyecare services in the US....

An anterior segment lump: a diagnostic and treatment challenge

2 February 2024 | | EYE - Oncology, EYE - Pathology
Case presentation A 50-year-old female presented to eye casualty with a lump on the left medial lower eyelid with associated redness and occasional bleeding. The lump was present for a few months with recent enlargement (Figure 1). Her past medical...

Chemical injury

6 April 2021 | | EYE - Cornea, EYE - General
You are the on-call ophthalmologist. You receive a call from A&E regarding a 45-year-old man who sustained a chemical injury. He was mixing some cement, when a small amount entered his left eye. He was not wearing any protective goggles....

Ocular mucous membrane pemphigoid: the importance of early detection and treatment

1 August 2014 | | EYE - Oculoplastic, EYE - Orbit
Mucous membrane pemphigoid (MMP) is an autoimmune blistering disorder that is characterised by subepithelial bullae. The ocular manifestation of MMP, ocular mucous membrane pemphigoid (OMMP), is a sight-threatening condition characterised by conjunctival cicatricial changes associated with corneal vascularisation and scarring....