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Inflammation and microvascular changes in diabetic retinopathy

Studies have shown that neurodegeneration and inflammation in the retina start early in diabetic retinopathy (DR) and can be present before the latter is clinically evident. The aim of this retrospective review of 99 diabetic patients was to evaluate retinal...

Exploring the potential of neurodegenerative disease screening within age-related eye disease research

The authors recruited healthy controls aged between 60 and 75-years-old, previously enrolled into a registry as patients following cataract surgery without age-related macular degeneration (AMD). Exclusion criteria included dense cataract, retinal disease, ocular inflammatory disease, moderate glaucoma, optic neuropathy, cancer,...

Patient reported outcomes in adolescents with inherited retinal diseases

This was a two-centre validation study of two sets of patient reported outcome measures (PROMS) for adolescents (13-17- years-old) with inherited retinal diseases. The measures were the Michigan Retinal Degeneration Questionnaire (MRDQ) and the Michigan Vision-Related Anxiety Questionnaire (MVAQ). Both...

Effects of ML4 on the eye

Mucolipidosis type IV (ML4) is an autosomal recessive lysosomal storage disease and is caused by variants of the MC0LN1 gene. It often presents in young individuals with eye and ocular adnexa issues. The authors present a case report and literature...

A case report of Horner syndrome with neuromyelitis optica

This case report details a patient diagnosed with neuromyelitis optica (NMO) with an associated left Horner syndrome. The female patient presented with neck pain and right hemibody decreased pain and temperature sensation. She then went on to develop left ptosis...

Corneal neurotisation with an allograft

This is the first reported use of an acellular nerve allograft for corneal neurotisation. Seven patients received a 7cm long commercially prepared acellular nerve allograft. This was coapted to a functioning supratrochlear, supraorbital or infraorbital nerve and then tunnelled to...

Sjogren’s syndrome in association with ophthalmoplegia

This is a case report of a 28-year-old female complaining of horizontal and vertical diplopia with inability to move her right eye and sudden onset right ptosis. She complained of retro-orbital pain with headache and a foreign body sensation in...