You searched for "regeneration"
Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy
The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...
Erythropoietin in healing corneal epithelial defects in rabbits
Corneal epithelial defects heal slowly in patients with diabetes, limbal stem cell deficiency and severe chemical burns. Erythropoietin is a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors as well as nonhematopoietic cells. In...
Control of bleeding with diabetic vitrectomy under air
The authors describe a modified diabetic vitrectomy using continuous air infusion in diabetic eyes with severe fibrovascular proliferation. In their case series of 25 eyes (20 patients), intravitreal bevacizumab (1.25mg) was used one week prior to surgery. Fifteen eyes had...
Possible mechanism for infant development of secondary glaucoma
The authors consider published evidence with regard to potential causative mechanisms for secondary glaucoma that follows infant lensectomy. They review clinical and laboratory studies. The mechanism they propose is that the original lensectomy surgery releases immature anterior lens cells into...
Clinical characteristics and visual outcome of patients with macular pseudohole
This is a retrospective study of consecutive patients with macular pseudohole (MPH) who had vitrectomy and were followed for at least 6 months postoperatively. MPH was diagnosed based on spectral-domain optical coherence tomography (OCT) findings. 76 eyes of 75 patients...Globes in space: What would happen to our globes on the globe of Mars?
Many films have been made regarding life on alternative planets. With the Mars One mission approaching in 2023, there are high expectations regarding future interplanetary travel. The authors provide an ophthalmology perspective on what could happen to our eyes if...The work of BIPOSA
The British and Irish Paediatric Ophthalmology and Strabismus Association (BIPOSA) was set up in 2008 to merge two streams of ophthalmology, namely the practice of paediatric ophthalmology and the practice of strabismus (to include refracting in children, and strabismus in...High score
Louie: “Allow me to present Pac-Man. Now, who is going to be the lucky pup who gets to play the first game? Iggy! You’re a somewhat compulsive personality. Step forward. Now… you see there’s the maze.” Iggy: “Uh-huh” Louie: “All...
