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RPTP-σ increases pro-MMP activity in a trabecular meshwork cell line following oxidative stress conditions

This study aims to outline the role of phosphatases in the aqueous drainage system by overexpressing receptor tyrosine phosphatase sigma (RPTP-σ) in a human normal trabecular meshwork cell line and describing its effect on subtypes of matrix metalloproteinases (MMP) and...

Evaluation of ectopia lentis et pupillae (ELP)

The ADAMTSL4 gene encodes proteins for cellular adhesion, angiogenesis, nervous system development and anterior / posterior segment structures. This case report describes a four-year-old female with diagnosis at referral of ELP. A three-generation pedigree was obtained and was negative for...

Large series profiling skew deviation

A retrospective notes review was completed for patients identified as having skew deviation. The authors outline their exact definition of skew deviation within the methods of the paper. One hundred and fifty-seven patients were identified, it is not clear over...

Would automated pupillometry be a useful addition when assessing acute vision loss?

The authors present a two-part study, the first part being an electronic survey of ophthalmologists and optometrists to identify barriers to the routine clinical use of automated pupillometry and the second, a clinical study comparing the swinging light tests and...

Causes of photophobia in adults and children

This retrospective case review identified individuals of any age with visual discomfort using billing records over an eight-year period. These records were screened for photophobia / light sensitivity as a main symptom or documented during examination. Data including demographics, medical...

Use of oral fluorescein angiography in a paediatric population

The authors report a retrospective records review of all patients who received an oral ultrawide fluorescein angiography (FA) over a 42-month period at a single children’s hospital. Data were extracted from the records including indication for FA, adverse events, pauses...

How common are carotid-cavernous fistulas and what are the neuro-ophthalmic manifestations?

The authors present a retrospective study using the Rochester Epidemiology Project database. The aim was to establish the incidence of carotid-cavernous fistulas (CCF) and outline the associated neuro-ophthalmic patterns. Cases were identified from the database using the following criteria: a...