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A possible biomarker for diabetic retinopathy
Diabetic retinopathy (DR) is the most common form of diabetic eye disease, characterised by exudates, microaneurysms and haemorrhage. Early diagnosis is crucial for preventing visual loss. The risk of developing diabetic retinopathy is known to increase with age as well...
Somatostatin protects retinal pericytes
Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood sugar levels damaging the retinal microvasculature. Mechanisms, such as oxidative stress and deposition of advanced glycation end products, leads to glial cell activation and neuronal apoptosis. Pericytes, contractile...
Adolescent optic disc haemorrhages
The authors conducted this study to describe the clinical characteristics of multi-layered optic disc haemorrhages in adolescents. This was a retrospective review of 16 eyes (11 right and five left) of 16 patients with a mean age of 15 ±2.6...
Ocular ischaemic syndrome in a rat model
Ocular Ischaemic syndrome is a devastating eye disease caused by severe carotid stenosis. This study’s purpose was to develop a reliable rat model for this syndrome by subjecting rats to common carotid artery occlusion and sham surgery. Rats were assigned...
Investigation of blood platelet parameters in anterior ischaemic optic neuropathy
The aim of this clinical retrospective comparative study was to assess the possible relationship between arteritic anterior ischaemic optic neuropathy (AAION) and non-arteritic anterior ischaemic optic neuropathy (NAION) with blood platelet parameters and neutrophil-to-lymphocyte ratio (NLR). The medical records of...
OCT-A imaging in Grave’s orbitopathy and orbital decompression
In this case series of 12 patients and 24 orbits, the authors describe the changes in the optic nerve and peripapillary blood vessel density in patients with moderate to severe Grave’s Orbitopathy (GO) undergoing orbital decompression. The patients undergoing orbital...
Colour Doppler imaging before and after orbital decompression in thyroid eye disease
In this prospective, uncontrolled study euthyroid patients with moderate to severe inactive thyroid eye disease underwent colour Doppler imaging before and after orbital decompression. Patients with dysthyroid optic neuropathy, corneal breakdown, systemic disease (diabetes, cerebrovascular accident, cardiovascular and peripheral vascular...
Congenital aniridia with or without retinal detachment
The authors present the clinical and molecular genetic evaluations performed on a large Iranian pedigree with 26 aniridia affected patients in four generations and some with retinal detachment. Members of the family affected with aniridia were invited to participate after...
Transient visual loss caused by crowded optic discs
The author presents four cases of transient visual loss (TVL) in young females (age range at presentation 14-22 years) with crowded optic discs. Patient demographics, investigations, medical and social histories are provided for all patients. A review of evidence for...
Laser speckle contrast imaging (LSCI) enables perfusion monitoring of the anterior segment during strabismus surgery: a study on the horizontal rectus muscles
Forty-four eyes with horizontal strabismus surgery involving medial and / or lateral rectus muscle detachment were recruited. The perfusion in the adjacent paralimbal and iris tissue was monitored with LSCI technique, by using a PeriCam PSI NR System. An infrared...
