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Management of a giant pigment epithelium detachment with transition from half- to full-dose aflibercept
This case report describes the management of a giant pigment epithelial detachment (PED) in neovascular age-related macular degeneration (nAMD) using half-dose aflibercept. An 80-year-old woman presented with a huge PED (maximum height 1338µm) and multiple risk factors for retinal pigment...The results of the last survey Jun22
Thank you once more for your time in answering the latest survey. The first question relates to the number of staff required for a routine cataract list. There was a big variance in practice. Some of us are luckier than...Here comes the fear
“At a cardiac arrest, the first procedure is to take your own pulse” The quote above is the Fat Man’s third law from the book The House of God by Samuel Shem, previously described in the ‘Doctor by the sea’...Jury duty
Until a few years ago doctors were exempt from jury duty. I am glad that this exemption was lifted as the stint I did at the crown court in Swansea recently was one of the most illuminating two weeks I...
DIY IOP – does it work?
Measuring intraocular pressure (IOP) plays a major role in glaucoma care as IOP is a parameter, along with visual field progression and optic disc cupping used to assess treatment effect. While Goldmann tonometry (GAT) is the gold standard, it only...
Importing iron to the retina
In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...
An alternative to povidone-iodine for intravitreal injections?
While povidone-iodine (5% aqueous) preparations have historically been considered the most effective antimicrobial prophylaxis for ophthalmic procedures and have been adopted as routine for intravitreal injections, post-procedure pain is a commonly recognized adverse event of IVI and has typically been...
Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
MicroRNA mediate retinoblastoma signal transduction
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
Scheimpflug vs. OCT in measuring corneal thickness
The authors report on the reproducibility and repeatability of corneal thickness measurements using three different Scheimpflug imaging cameras (Pentacam, Sirius and Galilei) and one Fourier-domain optical coherence tomography (OCT) system (RTvue-100). The rationale for this study is that corneal thickness...
