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Journal of Neuro-Ophthalmology front cover image.

Non-arteritic anterior ischaemic optic neuropathy in the Asian population

1 October 2014 | | EYE - Neuro-ophthalmology
This article provides an evaluation of changes in visual function associated with non-arteritic anterior ischaemic optic neuropathy (NAION) among Korean patients. Visual changes were identified as a reduction in visual acuity by three Snellen lines or a deterioration of visual...
Case Reports in Ophthalmology journal cover image

Unique case of steroid-induced intraocular pressure spike causing NAION

7 April 2021 | | EYE - Neuro-ophthalmology | Herpes zoster, Intraocular pressure, Ischemic optic neuropathy, NAION
The literature describes previous cases of nonarteritic anterior ischaemic optic neuropathy (NAION) following rapid rises in intraocular pressure (IOP) leading to reduced optic nerve head perfusion and disruption. This is commonly following ophthalmic procedures, acute glaucoma or steroid eye drops....
Seminars in Ophthalmology journal front cover image.

G-CSF intravitreal injections for NAION: a pilot study

5 April 2022 | | EYE - Neuro-ophthalmology | Anterior ischemic optic neuropathy, Granulocyte colony-stimulating factor, Intravitreal injection, Neuroprotection, Optic atrophy
In rodent models with anterior ischemic optic neuropathy (AION), granulocyte colony-stimulating factor (G-CSF) confers a neuroprotective effect on retinal ganglion cells (RGCs) via anti-apoptotic and anti-inflammatory processes. This prospective study investigated the efficacy of intravitreal injection of G-CSF for the...
Neuro-ophthalmology front cover image.

Visual prognosis in Irish Leber’s hereditary optic neuropathy

1 December 2022 | | EYE - Neuro-ophthalmology | Leber’s hereditary optic neuropathy, idebenone, inherited optic neuropathy, mtDNA, ophthalmic genetics, optic atrophy
Leber’s hereditary optic neuropathy (LHON) is an inherited optic neuropathy This paper presents a retrospective review of clinical data from patients with LHON presenting to an Irish tertiary referral ophthalmic hospital. Clinical and genetic characteristics were assessed for useful biomarkers...

Toxic nutritional optic neuropathy (TON)

2 August 2022 | | EYE - General
Toxic optic neuropathy are a group of conditions manifested by reduction of visual functions secondary to damage to the anterior visual pathways from exposure to a toxin. The implicated toxin could be work-based, food or drink related, or iatrogenic medication....
Seminars in Ophthalmology journal front cover image.

Review of non-arteritic anterior ischaemic optic neuropathy

1 October 2016 | | EYE - Neuro-ophthalmology | Neuroprotection, optic nerve ischemia, optic nerve vasculature, primate models, rodent models
This article reviews the risk factors, clinical presentation and therapies that have been investigated for non-arteritic anterior ischaemic optic neuropathy (NAAION). Additionally, it provides an update from recent rodent and primate models, offering a new insight into the pathophysiology of...

Rare eye diseases: progress continues with authorised orphan medicines and breakthrough technologies

1 October 2018 | | EYE - General
An update on the development of orphan medicines, recent regulatory treatment approvals for rare eye conditions and advances in retinal prosthetic technologies for blinding diseases. The prevalence of a rare disease is based usually on a range of estimates and...

Eye research: where next?

1 December 2017
Eye research in the UK is underfunded relative to other areas of medical research and general awareness of sight loss and its prevention remains poor, messages that were reinforced in presentations and discussions during a recent research summit meeting in...

25 years of OCT

1 December 2016 | | EYE - Vitreo-Retinal, EYE - Imaging
David Huang first described optical coherence tomography (OCT) in 1991, in his seminal paper on the subject in Science. This method developed the work of others on ophthalmic interferometry, which essentially showed that measuring reflected light could be used to...

The Global Vision Database

1 December 2015 | | EYE - General
The overall goal of the Global Vision Database (GVD) [1] is to develop and deploy new and improved evidence on the prevalence of blindness and vision impairment (VI) globally. It is a repository which allows us to assess the causes...

Initiatives in macular service provision

1 December 2015 | | EYE - Vitreo-Retinal
A report from Monitor in October 2015 identifies good practices that will realise most of the potential productivity gain in elective care available to NHS hospitals. These include: stratifying patients by risk and creating low-complexity pathways for lower-risk patients (tailoring...

Strategies for managing neovascular AMD and DMO in routine clinical care

1 October 2015 | | EYE - Vitreo-Retinal
Treatment practice in the management of neovascular age-related macular degeneration (AMD) and diabetic macular oedema (DMO) illustrate increasing adoption of patient-tailored treatment approaches based on initial diagnosis and regular monitoring of imaging and visual outcomes in routine clinical care. The...